PIKFYVE / PIP5K

Phosphoinositide Kinase, FYVE Finger Containing

Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PIKFYVE / PIP5K (8)

Publications

No (8)

Tag

GST (2)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human PIKFYVE / PIP5K Protein (Recombinant GST) (Full Length) - LS-G36954

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PIKFYVE / PIP5K Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93558

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

20 µg/$215

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Mouse PIKFYVE / PIP5K Protein (Recombinant His-T7) (aa1680-1931) - LS-G16137

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.0 kDa

Price:

10 µg/$277; 50 µg/$420; 100 µg/$670; 200 µg/$837; 1 mg/$1,928; 500 µg/$1,474; 5 mg/$2,927; 2 mg/$2,113

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PIKFYVE / PIP5K Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106117

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

100 µg/$710

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Human PIKFYVE / PIP5K Protein (Recombinant His, N-Terminal) - LS-G144362

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

62 kDa

Price:

50 µg/$419

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Human PIKFYVE / PIP5K Protein (Recombinant GST) - LS-G132236

Tag:

GST

Molecular Weight:

37.84kDa

Price:

10 µg/$479; 25 µg/$670

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Human PIKFYVE / PIP5K Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72778

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50 kDa

Price:

20 µg/$1,107

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Human PIKFYVE / PIP5K Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72777

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62 kDa

Price:

20 µg/$1,107

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