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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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PIK3R2 / p85 Beta
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317).
| Gene Name: | phosphoinositide-3-kinase, regulatory subunit 2 (beta) |
| Family/Subfamily: | Non-Protein Kinase , not assigned-Non-Protein Kinase |
| Synonyms: | PIK3R2, p85, p85B, p85-BETA, PI3K regulatory subunit beta, MPPH, PI3-kinase subunit p85-beta |
| Target Sequences: | NM_005027 NP_005018.1 O00459 |
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