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PIGM is a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum.
Gene Name: | phosphatidylinositol glycan anchor biosynthesis, class M |
Synonyms: | PIGM, GPI-MT-I, GPI mannosyltransferase 1, GPI mannosyltransferase I, PIG-M, PIG-M mannosyltransferase |
Target Sequences: | AB028127 BAB18567.1 Q9H3S5 |
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