PIF1

PIF1 5'-to-3' DNA helicase

DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.

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Products

Proteins (2)

Type

Over-Expression Lysate (2)

Target

PIF1 (2)

Publications

No (2)

Tag

Myc-DDK (Flag) (2)

Species

Human (1)

Source

293T Cells (1)

HEK 293 Cells (1)

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PIF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109618

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.6 kDa

Price:

100 µg/$710

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Human PIF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91902

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

69.6 kDa

Price:

20 µg/$215

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