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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PICK1

protein interacting with PRKCA 1

Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.

Gene Name: protein interacting with PRKCA 1
Synonyms: PICK1, DJ1039K5, PRKCABP, Protein interacting with PRKCA, PRKCA-binding protein, PICK
Target Sequences: NM_012407 NP_036539.1 Q9NRD5

Publications (1)

1
Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. Bassan M, Liu H, Madsen KL, Armsen W, Zhou J, Desilva T, Chen W, Paradise A, Brasch MA, Staudinger J, Gether U, Irwin N, Rosenberg PA. The European journal of neuroscience. 2008 27:66-82. [PubMed:18184314]

Viewing 1-25 of 47 items
PICK1 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Goat Polyclonal to Human PICK1
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Rabbit, Mouse, Dog, Human, Monkey
IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $355.00
PICK1 Antibody - Immunohistochemistry of paraffin-embedded human colon tissue.
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
PICK1 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using PICK1 Antibody at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human PICK1
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
PICK1 Antibody - Western blot. All lanes: Acid-sensing ion channel 3 antibody at 2 ug/ml+mouse brain tissue. Secondary antibody: goat polyclonal to Rabbit IgG at 1:10000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
ELISA, IHC, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
PICK1 Antibody - Western blot. All lanes: Acid-sensing ion channel 3 antibody at 2 ug/ml+mouse brain tissue. Secondary antibody: goat polyclonal to Rabbit IgG at 1:10000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
ELISA, IHC, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
PICK1 Antibody - Western blot. All lanes: Acid-sensing ion channel 3 antibody at 2 ug/ml+mouse brain tissue. Secondary antibody: goat polyclonal to Rabbit IgG at 1:10000 dilution. Predicted band size: 47 kDa. Observed band size: 47 kDa. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
ELISA, IHC, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
PICK1 Antibody - Western blot analysis of rat brain lysates using PICK1 antibody. The lane on the left is treated with the antigen-specific peptide.
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Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
IF, IHC
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Human
IF, IHC
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
PICK1 Antibody - PICK1 Antibody - IHC of PICK1 on mouse bladder.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Chicken Polyclonal (IgY) to Rat PICK1
Mouse, Rat
IF, IHC, IHC-P, IP, WB
Biotin Conjugated
100µl   $365.00
PICK1 Antibody - PICK1 Antibody - IHC of PICK1 on mouse bladder.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Chicken Polyclonal (IgY) to Rat PICK1
Mouse, Rat
IF, IHC, IHC-P, IP, WB
DY650 Conjugated
100µl   $365.00
PICK1 Antibody - PICK1 Antibody - IHC of PICK1 on mouse bladder.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Chicken Polyclonal (IgY) to Rat PICK1
Mouse, Rat
IF, IHC, IHC-P, IP, WB
DY488 Conjugated
100µl   $365.00
PICK1 Antibody - PICK1 Antibody - IHC of PICK1 on mouse bladder.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Chicken Polyclonal (IgY) to Rat PICK1
Mouse, Rat
IF, IHC, IHC-P, IP, WB
DY550 Conjugated
100µl   $365.00
PICK1 Antibody - Western blot.
Select
Rabbit Polyclonal to Human PICK1
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PICK1
Mouse, Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal to Human PICK1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00

Viewing 1-25 of 47 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).