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PIAS3

protein inhibitor of activated STAT, 3

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Gene Name: protein inhibitor of activated STAT, 3
Synonyms: PIAS3, E3 SUMO-protein ligase PIAS3, ZMIZ5
Target Sequences: NM_006099 NP_006090.2 Q9Y6X2

Publications (3)

1
PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. Iwasaki K, Hailemariam K, Tsuji Y. The Journal of biological chemistry. 2007 282:22335-43. [PubMed:17565989] [PMC:PMC2409283]
2
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human) [Full Text Article] [PubMed:26937035] [PMC:PMC4836348]
3
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human) [Full Text Article] [PubMed:27099310] [PMC:PMC4907222]

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ELISA Kits (10)
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PIAS3 (10)
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PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
2.5 - 160 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
PIAS3 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
PIAS3 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
PIAS3 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
PIAS3 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
PIAS3 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).