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PIAS3

protein inhibitor of activated STAT, 3

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

Gene Name: protein inhibitor of activated STAT, 3
Synonyms: PIAS3, E3 SUMO-protein ligase PIAS3, ZMIZ5
Target Sequences: NM_006099 NP_006090.2 Q9Y6X2

Publications (3)

1
PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element. Iwasaki K, Hailemariam K, Tsuji Y. The Journal of biological chemistry. 2007 282:22335-43. [PubMed:17565989] [PMC:PMC2409283]
2
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response. Conn KL, Wasson P, McFarlane S, Tong L, Brown JR, Grant KG, Domingues P, Boutell C. Journal of virology. 2016 90:4807-26. (ICC, WB; Human) [Full Text Article] [PubMed:26937035] [PMC:PMC4836348]
3
SUMO Ligase Protein Inhibitor of Activated STAT1 (PIAS1) Is a Constituent Promyelocytic Leukemia Nuclear Body Protein That Contributes to the Intrinsic Antiviral Immune Response to Herpes Simplex Virus 1. Brown JR, Conn KL, Wasson P, Charman M, Tong L, Grant K, McFarlane S, Boutell C. Journal of virology. 2016 90:5939-52. (ICC, WB; Human) [Full Text Article] [PubMed:27099310] [PMC:PMC4907222]

☰ Filters
Products
Antibodies (36)
Primary (36)
PIAS3 (36)
Human (36)
Mouse (13)
Rat (19)
Bovine (7)
Chimpanzee (3)
Dog (7)
Guinea pig (3)
Horse (6)
Monkey (3)
Pig (4)
Rabbit (3)
IHC (18)
IHC-P (10)
WB (30)
ELISA (8)
IF (4)
Peptide-ELISA (2)
rabbit (36)
Product Group
IHCPlus (2)
IgG (19)
polyclonal pc (36)
APC (1)
APC Conjugated (1)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (23)
aa11-280 (8)
aa395-444 (4)
aa548-597 (4)
10-90 aa, N-terminal (1)
N-Terminus (1)
Phe25 (1)
aa10-59 (1)
aa274-521 (1)
aa399-628 (1)
No (36)
PIAS3 Antibody - Anti-PIAS3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
PIAS3 Antibody - Anti-PIAS3 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PIAS3 Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PIAS3 Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PIAS3 Antibody - Immunohistochemistry of paraffin-embedded rat brain tissue.
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PIAS3 Antibody - Western blot of PIAS 3 antibody
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PIAS3 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PIAS3 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
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PIAS3 Rabbit anti-Human Polyclonal (aa399-628) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
PIAS3 Antibody - PIAS3 antibody ARP32762_T100-NP_006090-PIAS3 (protein inhibitor of activated STAT, 3) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PIAS3 Rabbit anti-Human Polyclonal (aa548-597) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
PIAS3 Antibody - PIAS3 antibody ARP32762_T100-NP_006090-PIAS3 (protein inhibitor of activated STAT, 3) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PIAS3 Rabbit anti-Human Polyclonal (aa548-597) (HRP) Antibody
Dog, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
PIAS3 Antibody - PIAS3 antibody ARP32762_T100-NP_006090-PIAS3 (protein inhibitor of activated STAT, 3) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PIAS3 Rabbit anti-Human Polyclonal (aa548-597) (Biotin) Antibody
Dog, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
PIAS3 Antibody - PIAS3 antibody ARP32762_T100-NP_006090-PIAS3 (protein inhibitor of activated STAT, 3) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PIAS3 Rabbit anti-Human Polyclonal (aa548-597) (FITC) Antibody
Dog, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
PIAS3 Antibody - IHC of PIAS3 (F25) pAb in paraffin-embedded human lung carcinoma tissue.
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PIAS3 Rabbit anti-Human Polyclonal (Phe25) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
PIAS3 Antibody - Immunohistochemical analysis of PIAS3 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PIAS3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PIAS3 Antibody - Western blot of 293 cell lysate using PIAS3 Antibody
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
PIAS3 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using PIAS3 Polyclonal Antibody at dilution of 1:55(×200)
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PIAS3 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using PIAS3 Polyclonal Antibody at dilution of 1:40(×200)
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PIAS3 Antibody
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PIAS3 Rabbit anti-Human Polyclonal (aa274-521) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$332
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PIAS3 Antibody - Immunofluorescence analysis of U2OS cells using PIAS3 antibody.
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PIAS3 Antibody - PIAS3 antibody Western blot of Fetal Spleen lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PIAS3 Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$424
PIAS3 Antibody - Western blot - Anti-PIAS3 Picoband antibody
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
PIAS3 Antibody - Western blot of PIAS3 antibody.
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PIAS3 Rabbit anti-Human Polyclonal (aa11-280) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
PIAS3 Antibody - Western blot testing of human 1) HeLa, 2) U-87 MG, 3) COLO320, 4) HepG2, 5) rat brain and 6) mouse NIH3T3 lysate with PIAS3 antibody at 0.5ug/ml. Predicted molecular weight ~68 kDa.
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PIAS3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$575
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).