PIAS2 / PIASX

protein inhibitor of activated STAT, 2

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.

☰ Filters

Products

Antibodies (56)

Proteins (7)

Type

Over-Expression Lysate (4)

Primary (56)

Recombinant (3)

Target

PIAS2 / PIASX (63)

Reactivity

Human (48)

Mouse (28)

Rat (21)

Bat (2)

Bovine (11)

Chicken (2)

Chimpanzee (9)

Dog (18)

Gibbon (6)

Guinea pig (6)

Horse (14)

Monkey (12)

Rabbit (14)

more less

Application

IHC (21)

IHC-P (4)

WB (54)

ELISA (16)

IF (3)

Peptide-ELISA (4)

Host

rabbit (49)

mouse (4)

goat (2)

sheep (1)

Product Group

IHCPlus (2)

Isotype

IgG (36)

IgG1 (4)

Clonality

monoclonal mc (4)

polyclonal pc (52)

Clone

OTI2B5 (2)

OTI5B4 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (8)

Carrier-free (2)

FITC Conjugated (8)

HRP Conjugated (8)

PE Conjugated (1)

Unconjugated (30)

Epitope

C-Terminus (12)

aa518-547 (7)

aa1-572 (4)

aa51-100 (4)

aa58-107 (4)

aa81-130 (4)

10-90 aa, N-terminal (1)

Gly24 (1)

N-Terminus (1)

aa1-30 (1)

aa1-550 (1)

aa10-59 (1)

aa185-196 (1)

aa431-445 (1)

aa532-621 (1)

more less

Publications

No (62)

Yes (1)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

PIAS2 / PIASX Antibody LS-C108717

(4.1) Rating

(2) Publication(s)

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

Select

PIAS2 / PIASX Antibody LS-C800393

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PIAS2 / PIASX Antibody LS-C341276

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

Select

IHC-plus™ PIAS2 / PIASX Antibody (aa10-59) LS-B11347

(4.0) Rating

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa10-59) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$515

Select

IHC-plus™ PIAS2 / PIASX Antibody (aa431-445) LS-B3240

(4.0) Rating

Antibody:

PIAS2 / PIASX Goat anti-Human Polyclonal (aa431-445) Antibody

Reactivity:

Rabbit, Dog, Horse, Bat, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

Select

PIAS2 / PIASX Antibody (aa518-547) LS-C328233

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PIAS2 / PIASX Antibody (aa518-547, Biotin) LS-C245316

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PIAS2 / PIASX Antibody (aa518-547, FITC) LS-C245317

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PIAS2 / PIASX Antibody (aa518-547, Azide-free, HRP) LS-C247758

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

PIAS2 / PIASX Antibody (aa518-547, APC) LS-C245315

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PIAS2 / PIASX Antibody (aa518-547, PE) LS-C245318

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

PIAS2 / PIASX Antibody (aa1-572) LS-C370791

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

PIAS2 / PIASX Antibody (aa1-572, HRP) LS-C370789

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PIAS2 / PIASX Antibody (aa1-572, Biotin) LS-C370792

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PIAS2 / PIASX Antibody (aa1-572, FITC) LS-C370790

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-572) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PIAS2 / PIASX Antibody (aa518-547) LS-C98797

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa518-547) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PIAS2 / PIASX Antibody (C-Terminus) LS-C30501

Antibody:

PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PIAS2 / PIASX Antibody (C-Terminus, HRP) LS-C434940

Antibody:

PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Mouse, Dog, Rat, Horse

Applications:

IHC, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PIAS2 / PIASX Antibody (C-Terminus, Biotin) LS-C434939

Antibody:

PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Dog, Rat, Horse

Applications:

IHC, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PIAS2 / PIASX Antibody (C-Terminus, FITC) LS-C434938

Antibody:

PIAS2 / PIASX Rabbit anti-Mouse Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Mouse, Dog, Rat, Horse

Applications:

IHC, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PIAS2 / PIASX Antibody (aa1-30) LS-C98799

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PIAS2 / PIASX Antibody LS-C402922

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

PIAS2 / PIASX Antibody LS-C334194

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

PIAS2 / PIASX Antibody LS-C754000

Antibody:

PIAS2 / PIASX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

PIAS2 / PIASX Antibody (clone OTI5B4) LS-C794354

Antibody:

PIAS2 / PIASX Mouse anti-Human Monoclonal (OTI5B4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Viewing 1-25 of 63 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.