PIAS1

protein inhibitor of activated STAT, 1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PIAS1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (1)

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Human PIAS1 Protein (Recombinant GST, N-terminus) (aa543-651) - LS-G60779

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIAS1 Protein (Recombinant GST, N-terminus) (aa476-565) - LS-G60780

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81822

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.7 kDa

Price:

20 µg/$215

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Human PIAS1 Protein (Recombinant His-T7) (aa409-645) - LS-G14214

Source:

E. coli

Tag:

His-T7

Molecular Weight:

29.4 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136

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Human PIAS1 Protein (Recombinant GST) (Full Length) - LS-G31203

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

98.2 kDa

Price:

2 µg/$439

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PIAS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101396

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71.7 kDa

Price:

100 µg/$710

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