PIAS1

protein inhibitor of activated STAT, 1

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation (By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation.

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Products

ELISA Kits (11)

Type

Cell-Based (1)

Sandwich (9)

Sandwich CLIA (1)

Target

PIAS1 (11)

Reactivity

Human (2)

Mouse (4)

Rat (1)

Chicken (1)

Guinea pig (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (8)

Publications

No (11)

Sample Type

Adherent Cell Cultures (1)

Plasma (5)

Serum (5)

Tissue Homogenates (1)

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Chicken PIAS1 (Sandwich ELISA) ELISA Kit - LS-F47324

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Guinea pig PIAS1 (Sandwich ELISA) ELISA Kit - LS-F47328

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Monkey PIAS1 (Sandwich ELISA) ELISA Kit - LS-F47329

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine PIAS1 (Sandwich ELISA) ELISA Kit - LS-F47330

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rabbit PIAS1 (Sandwich ELISA) ELISA Kit - LS-F47331

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

3.125 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Mouse PIAS1 (Sandwich ELISA) ELISA Kit - LS-F21439

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse PIAS1 (Sandwich ELISA) ELISA Kit - LS-F33677

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse PIAS1 (CLIA) ELISA Kit - LS-F30929

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Human PIAS1 (Sandwich ELISA) ELISA Kit - LS-F37892

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat PIAS1 (Sandwich ELISA) ELISA Kit - LS-F38683

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse/Human PIAS1 (Cell-Based ELISA) ELISA Kit - LS-F2242

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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