PHLPP2 / PHLPPL

PH domain and leucine rich repeat protein phosphatase 2

Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PHLPP2 / PHLPPL (3)

Publications

No (3)

Tag

Myc-DDK (Flag) (3)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (2)

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PHLPP2 / PHLPPL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113524

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

146.6 kDa

Price:

100 µg/$710

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Human PHLPP2 / PHLPPL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72670

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

146.6 kDa

Price:

20 µg/$1,107

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Human PHLPP2 / PHLPPL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93230

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

146.6 kDa

Price:

20 µg/$215

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