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PHGDH

phosphoglycerate dehydrogenase

PHGDH encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known.

Gene Name: phosphoglycerate dehydrogenase
Synonyms: PHGDH, 3-PGDH, 3PGDH, PGDH, Phosphoglycerate dehydrogenase, PDG, PGAD, PGDH3
Target Sequences: NM_006623 NP_006614.2 O43175

Publications (1)

1
High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman ML, Wielenga VT, Moreira JM. Molecular oncology. 2015 9:1636-54. (WB; Human) [Full Text Article] [PubMed:26026368] [PMC:PMC5528790] Related Antibodies: LS-B5457.

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Antibodies (46)
Primary (46)
PHGDH (46)
Human (46)
Mouse (12)
Rat (10)
Bat (3)
Chimpanzee (6)
Gibbon (6)
Hamster (6)
Horse (3)
Monkey (3)
Orangutan (6)
Pig (3)
Rabbit (3)
Zebrafish (3)
IHC (30)
IHC-P (13)
WB (43)
Flo (8)
ELISA (18)
ICC (3)
IF (5)
IP (7)
Peptide-ELISA (1)
rabbit (37)
mouse (9)
Product Group
IHCPlus (3)
IgG (32)
IgG1 (2)
IgG1,k (1)
IgG2a (2)
IgG2b (2)
monoclonal mc (9)
polyclonal pc (37)
4A3-1D6 (1)
OTI4A1 (2)
OTI5C4 (2)
OTI9C2 (2)
APC Conjugated (1)
Biotin Conjugated (5)
Carrier-free (3)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (1)
Preservative Free (1)
Unconjugated (29)
aa249-277 (7)
aa254-303 (4)
aa362-411 (4)
Internal (1)
aa1-50 (1)
aa140-168 (1)
No (45)
Yes (1)
PHGDH Antibody - Anti-PHGDH antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PHGDH Mouse anti-Human Monoclonal (4A3-1D6) Antibody
Human
ELISA, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
PHGDH Antibody - 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PHGDH Rabbit anti-Human Polyclonal (aa362-411) Antibody
Human
WB
Unconjugated
100 µl/$424
PHGDH Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PHGDH Rabbit anti-Human Polyclonal (aa254-303) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PHGDH Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PHGDH Rabbit anti-Human Polyclonal (aa254-303) (Biotin) Antibody
Zebrafish, Pig, Horse, Rabbit, Mouse, Rat, Hamster, Bat, Gibbon, Human, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
PHGDH Antibody - Immunochemical staining of human PHGDH in human breast carcinoma with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.
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PHGDH Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P, IP, WB
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
PHGDH Antibody - Immunochemical staining of human PHGDH in human breast carcinoma with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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PHGDH Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
PHGDH Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with PHGDH Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PHGDH Rabbit anti-Human Polyclonal (aa140-168) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PHGDH Antibody - 1:100 staining human lymph carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PHGDH Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) (FITC) Antibody
Human
Flo, IHC, WB
FITC Conjugated
200 µl/$952
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
PHGDH Antibody - PHGDH Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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PHGDH Rabbit anti-Human Polyclonal (aa249-277) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PHGDH Antibody - Anti-PHGDH / PGDH antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
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PHGDH Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PHGDH Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue using PHGDH Antibody at dilution of 1:100
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PHGDH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
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PHGDH Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IF
Unconjugated
100 µl/$412
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PHGDH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
PHGDH Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using PHGDH Antibody at dilution of 1:100
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PHGDH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
PHGDH Antibody - Detection of mouse PHGDH by immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti- PHGDH used at a dilution of 1:1,000 (1µg/ml). Detection: DAB
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PHGDH Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PHGDH Antibody - IHC of paraffin-embedded Human liver tissue using anti-PHGDH mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PHGDH Mouse anti-Human Monoclonal (OTI5C4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PHGDH Antibody - Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-PHGDH mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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PHGDH Mouse anti-Human Monoclonal (Carrier-free) (OTI5C4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PHGDH Antibody - IHC of paraffin-embedded Human liver tissue using anti-PHGDH mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PHGDH Mouse anti-Human Monoclonal (OTI9C2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PHGDH Antibody - Immunohistochemistry of paraffin-embedded rat lung using PHGDH antibodyat dilution of 1:100 (40x lens).
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PHGDH Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PHGDH Antibody - Immunochemical staining of human PHGDH in human breast carcinoma with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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PHGDH Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, IP, WB
Unconjugated
100 µl/$412
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).