PHF8

PHD finger protein 8

Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

PHF8 (3)

Publications

No (3)

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His-T7 (1)

Myc-DDK (Flag) (2)

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Human (1)

Mouse (1)

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293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Human PHF8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86116

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.3 kDa

Price:

20 µg/$215

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Mouse PHF8 Protein (Recombinant His-T7) (aa195-351) - LS-G25881

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.0 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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PHF8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130365

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

118.3 kDa

Price:

100 µg/$710

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