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PHF19
PHD finger protein 19
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases NO66 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.
| Gene Name: | PHD finger protein 19 |
| Synonyms: | PHF19, DKFZP727G051, MTF2L1, PHD finger protein 19, Polycomb like 3, Polycomb-like 3, PCL3, Polycomb-like protein 3, HPCL3 |
| Target Sequences: | AL117477 Q5T6S3 Q5T6S3 |
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