PHF1

PHD finger protein 1

Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (PubMed:18285464 and PubMed:23273982). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (PubMed:23142980). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

PHF1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PHF1 Protein (Recombinant GST, N-terminus) (aa2-100) - LS-G59588

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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PHF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110020

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.9 kDa

Price:

100 µg/$494

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Human PHF1 Protein (Recombinant GST) (Full Length) - LS-G29722

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

88.5 kDa

Price:

2 µg/$439

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Human PHF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80406

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61.9 kDa

Price:

20 µg/$150

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