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Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.
Gene Name: | polyhomeotic homolog 1 (Drosophila) |
Synonyms: | PHC1, HPH1, PH1, Polyhomeotic-like 1, Polyhomeotic-like protein 1, RAE28, EDR1 |
Target Sequences: | NM_004426 NP_004417.2 P78364 |
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