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Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Gene Name: | Phosphoglycerate Mutase Family Member 5 |
Synonyms: | PGAM5, Bcl-XL-binding protein v68, BXLBV68 |
Target Sequences: | NM_024989 NP_079265.2 |
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