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PFKP
phosphofructokinase, platelet
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.
| Gene Name: | phosphofructokinase, platelet |
| Synonyms: | PFKP, 6-phosphofructokinase type C, 6-phosphofructokinase, type c, PFK-C, PFKF, Phosphofructokinase 1, Phosphofructokinase, platelet, Phosphohexokinase |
| Target Sequences: | NM_002627 NP_002618.1 Q01813 |
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