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PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

PFKFB2 is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.

Gene Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
Synonyms: PFKFB2, 6PF-2-K/Fru-2,6-P2ase 2, PFK-2/FBPase-2, PFK/FBPase 2, PFKFB, cardiac
Target Sequences: NM_006212 NP_006203.2 O60825

Publications (1)

1
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. Di A, Kawamura T, Gao XP, Tang H, Berdyshev E, Vogel SM, Zhao YY, Sharma T, Bachmaier K, Xu J, Malik AB. The Journal of biological chemistry. 2010 285:15848-57. [PubMed:20299461] [PMC:PMC2871452] Related Antibodies: LS-C101286.

☰ Filters
Antibodies (40)
Proteins (7)
ELISA Kits (2)
Cell-Based (1)
Cell-Based Phosphorylation (1)
Over-Expression Lysate (4)
Primary (40)
Recombinant (3)
PFKFB2 (49)
Human (40)
Mouse (26)
Rat (20)
Bat (3)
Bovine (1)
Chicken (3)
Dog (6)
Gibbon (3)
Guinea pig (3)
Horse (6)
Monkey (8)
Orangutan (6)
Pig (3)
Rabbit (3)
Xenopus (3)
Zebrafish (3)
IHC (19)
IHC-P (6)
WB (34)
ELISA (16)
ICC (1)
IF (2)
IP (2)
Peptide-ELISA (4)
rabbit (39)
goat (1)
Product Group
IHCPlus (1)
IgG (24)
polyclonal pc (40)
96-Well Microplate (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (26)
aa1-30 (7)
pSer483 (5)
C-Terminus (4)
aa336-385 (4)
420-500 aa (2)
N-Terminus (1)
Pro479 (1)
Ser483 (1)
Tyr14 (1)
aa1-50 (1)
aa451-500 (1)
aa455-505 (1)
aa7-19 (1)
p483 (1)
No (48)
Yes (1)
Adherent Cell Cultures (2)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (4)
Human (5)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (1)
PFKFB2 Antibody - Anti-PFKFB2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
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PFKFB2 Goat anti-Human Polyclonal (aa7-19) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
PFKFB2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PFKFB2 Antibody - Western blot of PFK-2 car antibody
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PFKFB2 Rabbit anti-Human Polyclonal (420-500 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PFKFB2 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using PFKFB2 (Phospho-Ser483) Antibody. The picture on the right is blocked with the phospho peptide.
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PFKFB2 Rabbit anti-Human Polyclonal (pSer483) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PFKFB2 Antibody - Immunohistochemical analysis of PFKFB2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PFKFB2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
PFKFB2 Antibody - Western blot analysis of PFKFB2 (pS483) expression in HeLa H2O2-treated (A); SP2/0 H2O2-treated (B); H9C2 H2O2-treated (C) whole cell lysates.
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PFKFB2 Rabbit anti-Human Polyclonal (pSer483) Antibody
Mouse, Bovine, Rat, Human
WB
Unconjugated
100 µl/$315
PFKFB2 Antibody - Immunohistochemistry of paraffin-embedded human lung cancer using PFKFB2 Antibody at dilution of 1:100
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PFKFB2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
PFKFB2 ELISA Kit
Select
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
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PFKFB2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PFKFB2 Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PFKFB2 Antibody - Western blot of Phospho-PFK-2 car (S483) antibody
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PFKFB2 Rabbit anti-Human Polyclonal (420-500 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PFKFB2 Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PFKFB2 (Phospho-Ser483) antibody.
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PFKFB2 Rabbit anti-Human Polyclonal (pSer483) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PFKFB2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PFKFB2 (Ab-483) antibody.
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PFKFB2 Rabbit anti-Human Polyclonal (p483) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
PFKFB2 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using PFKFB2 Antibody. The picture on the right is blocked with the synthesized peptide.
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PFKFB2 Rabbit anti-Human Polyclonal (aa451-500) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PFKFB2 Antibody - Immunohistochemistry (IHC) analysis of PFK-2 car (Y14) pAb in paraffin-embedded human heart tissue.
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PFKFB2 Rabbit anti-Human Polyclonal (Tyr14) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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PFKFB2 Rabbit anti-Human Polyclonal (pSer483) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$328; 100 µl/$419
PFKFB2 Antibody - Western blot analysis of extracts from Jurkat cells, using PFKFB2 antibody.
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PFKFB2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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PFKFB2 Rabbit anti-Human Polyclonal (pSer483) Antibody
Mouse, Human
IP, WB
Unconjugated
20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539
PFKFB2 Antibody - Western blot analysis of lysates from Jurkat cells, using PFKFB2 Antibody. The lane on the right is blocked with the synthesized peptide.
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PFKFB2 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PFKFB2 Antibody - Detection of Human and Mouse PFKFB2 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-PFKFB2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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PFKFB2 Rabbit anti-Human Polyclonal (aa455-505) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 49 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).