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PFDN6 / HKE2

prefoldin subunit 6

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Gene Name:	prefoldin subunit 6
Synonyms:	PFDN6, KE-2, KE2 protein, HKE2, Prefoldin subunit 6, Prefoldin 6, PFD6, H2-KE2, Protein Ke2
Target Sequences:	NM_014260 NP_055075.1 O15212

Publications (1)

Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits. Miyazawa M, Tashiro E, Kitaura H, Maita H, Suto H, Iguchi-Ariga SM, Ariga H. The Journal of biological chemistry. 2011 286:19191-203. [PubMed:21478150] [PMC:PMC3103298] Related Antibodies: LS-C97157.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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