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PEX19

peroxisomal biogenesis factor 19

PEX19 is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.

Gene Name: peroxisomal biogenesis factor 19
Synonyms: PEX19, 33 kDa housekeeping protein, D1S2223E, Housekeeping gene, 33kD, PBD12A, PMPI, PXMP1, PXF, PMP1, HK33, Peroxin-19
Target Sequences: NP_002848.1 P40855

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Products
Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
PEX19 (9)
No (9)
10His-SUMO, N-terminus (1)
GST (1)
His (1)
His, N-Terminal (2)
Myc-DDK (Flag) (4)
Human (7)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (4)
Biologically active (1)
PEX19 Protein - Recombinant Peroxisomal Biogenesis Factor 19 (PEX19) by SDS-PAGE
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E. coli
His, N-Terminal
36.0kDa
10 µg/$243; 50 µg/$291; 200 µg/$402; 100 µg/$339; 1 mg/$1,156; 500 µg/$802; 5 mg/$1,982; 2 mg/$1,298
PEX19 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
100 µg/$494
PEX19 Protein - 12.5% SDS-PAGE of human PEX19 stained with Coomassie Blue
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Wheat Germ Extract
GST
58.63 kDa
10 µg/$479; 25 µg/$670
PEX19 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus
Biologically active
100 µg/$420; 1 mg/$1,355; 20 µg/$323
PEX19 Protein - Purified recombinant protein PEX19 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$1,107
PEX19 Protein - Purified recombinant protein PEX19 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
23.1 kDa
20 µg/$1,107
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293T Cells
Myc-DDK (Flag)
32.6 kDa
20 µg/$150
PEX19 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
PEX19 Protein - Recombinant Peroxisomal Biogenesis Factor 19 (PEX19) by SDS-PAGE
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E. coli
His, N-Terminal
35.9kDa
10 µg/$260; 50 µg/$335; 200 µg/$622; 100 µg/$497; 1 mg/$1,588; 500 µg/$1,185; 5 mg/$2,522; 2 mg/$1,760
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).