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PES1
pescadillo ribosomal biogenesis factor 1
PES1 is a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9.
| Gene Name: | pescadillo ribosomal biogenesis factor 1 |
| Synonyms: | PES1, Pescadillo homolog, PES |
| Target Sequences: | NM_014303 NP_055118.1 O00541 |
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