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PERP

PERP, TP53 apoptosis effector

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.

Gene Name: PERP, TP53 apoptosis effector
Synonyms: PERP, DJ496H19.1, KCP-1, PERP, TP53 apoptosis effector, KCP1, p53-induced protein PIGPC1, THW, KRTCAP1, PIGPC1, RP3-496H19.1, Transmembrane protein THW
Target Sequences: NM_022121 NP_071404.2 Q96FX8

Publications (2)

1
PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia. Singaravelu K, Devalaraja-Narashimha K, Lastovica B, Padanilam BJ. American journal of physiology. Renal physiology. 2009 296:F847-58. [PubMed:19158346]
2
Differential gene expression in normal esophagus and Barrett's esophagus. Wang J, Qin R, Ma Y, Wu H, Peters H, Tyska M, Shaheen NJ, Chen X. Journal of gastroenterology. 2009 44:897-911. (IHC-P; Human) [PubMed:19468668] Related Antibodies: LS-B1389.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).