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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PER1

period circadian clock 1

Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.

Gene Name: period circadian clock 1
Synonyms: PER1, HPER, HPER1, KIAA0482, Period circadian clock 1, Period, drosophila, homolog of, RIGUI, PER, Period (Drosophila) homolog 1, Period homolog 1 (Drosophila)
Target Sequences: NM_002616 NP_002607.2 O15534

Filtered By: None
Target
PER1 (50)
Reactivity
Human (44)
Mouse (11)
Rat (15)
Bat (8)
Bovine (2)
Chimpanzee (9)
Dog (1)
Drosophila (3)
Gibbon (6)
Guinea pig (12)
Hamster (4)
Horse (6)
Monkey (4)
Orangutan (3)
Pig (5)
Rabbit (4)
Application
IHC (15)
IHC-P (3)
WB (45)
DB (1)
ELISA (22)
ICC (2)
IF (2)
Host
rabbit (46)
mouse (1)
chicken (2)
sheep (1)
Isotype
IgG (30)
IgG1 (1)
IgY (1)
Clonality
monoclonal mc (1)
polyclonal pc (49)
Clone
2715C2 (1)
Format
AP Conjugated (1)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (6)
PE Conjugated (2)
Unconjugated (23)
Epitope
aa208-414 (10)
N-Terminus (8)
aa1156-1183 (8)
C-Terminus (5)
aa41-90 (4)
Internal (3)
aa1000-1200 (1)
aa1150-1200 (1)
aa30-80 (1)
aa788-905 (1)
Publications
No (50)
Showing 1-25 of 50 results

PER1 Antibody (N-Terminus) IHC-plus™ LS-B14003
Rabbit Polyclonal to Human PER1
Guinea pig, Rat, Human
IHC IHC-P WB
Unconjugated
50µg  $485.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of Human Breast Tumor. PER1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of Human Breast Tumor. PER1 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PER1 Antibody (C-Terminus) LS-C17237
Rabbit Polyclonal (IgG) to Drosophila PER1
Drosophila
ELISA WB
Unconjugated
100µg 100µl 1mg/ml  $755.00

PER1 Antibody (C-Terminus) LS-C17238
Rabbit Polyclonal to Drosophila PER1
Drosophila
ELISA WB
Unconjugated
100µl  $725.00

PER1 Antibody (aa30-80) LS-C148631
Rabbit Polyclonal to Mouse PER1
Mouse, Dog, Bovine, Pig, Horse, Human
IHC IHC-P
Unconjugated
100µg 0.5mg/ml  $335.00
IHC of PER1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Polyclonal Antibody to PER1 (bottom left, right) at 5 ug/ml.
IHC of PER1 in formalin-fixed, paraffin-embedded human brain tissue using an isotype control (top left) and Polyclonal Antibody to PER1 (bottom left, right) at 5 ug/ml.

PER1 Antibody (Internal) LS-C17243
Rabbit Polyclonal (IgG) to Mouse PER1
Mouse
ELISA IF IHC WB
Unconjugated
100µg  $755.00

PER1 Antibody LS-C755320
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

PER1 Antibody LS-C662671
Rabbit Polyclonal to Human PER1
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $355.00
Immunohistochemistry - Anti-PER1 Picoband antibody
Western blot - Anti-PER1 Picoband antibody
Immunohistochemistry - Anti-PER1 Picoband antibody
Western blot - Anti-PER1 Picoband antibody

PER1 Antibody LS-C409984
Rabbit Polyclonal (IgG) to Human PER1
Mouse, Rat, Human
IHC WB
Unconjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human gastric using PER1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat kidney using PER1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human gastric using PER1 antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded rat kidney using PER1 antibody at dilution of 1:100 (x40 lens).

PER1 Antibody LS-C502286
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA IHC
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100

PER1 Antibody (Internal) LS-C17239
Rabbit Polyclonal (IgG) to Mouse PER1
Mouse
ELISA WB
Unconjugated
100µl  $725.00

PER1 Antibody (aa208-414) LS-C373783
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,310.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, HRP) LS-C714559
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
HRP Conjugated
20µl  $225.00; 100µl  $305.00; 200µl  $365.00; 1ml  $755.00; 10ml  $3,000.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, Biotin) LS-C425140
Rabbit Polyclonal (IgG) to Human PER1
Human
ICC WB
Biotin Conjugated
100µl 0.5mg/ml  $395.00

PER1 Antibody (aa208-414, Biotin) LS-C689460
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
Biotin Conjugated
20µl  $215.00; 100µl  $275.00; 200µl  $325.00; 1ml  $635.00; 10ml  $2,535.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, FITC) LS-C425142
Rabbit Polyclonal (IgG) to Human PER1
Human
ICC WB
FITC Conjugated
100µl 0.5mg/ml  $415.00

PER1 Antibody (aa208-414, FITC) LS-C696576
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
FITC Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,775.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, Cy3) LS-C705546
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
Cy3 Conjugated
20µl  $255.00; 100µl  $375.00; 200µl  $465.00; 1ml  $1,155.00; 10ml  $4,620.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, APC) LS-C719669
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
APC Conjugated
20µl  $225.00; 100µl  $325.00; 200µl  $395.00; 1ml  $860.00; 10ml  $7,185.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, PE) LS-C728628
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
PE Conjugated
20µl  $215.00; 100µl  $285.00; 200µl  $345.00; 1ml  $695.00; 10ml  $2,775.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (aa208-414, APC, Cy7) LS-C737495
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC WB
APC, Cy7 Conjugated
20µl  $295.00; 100µl  $485.00; 200µl  $695.00; 1ml  $1,725.00; 10ml  $6,945.00
Western blot of PER1 antibody.
Western blot of PER1 antibody.

PER1 Antibody (C-Terminus) LS-C17241
Rabbit Polyclonal (IgG) to Human PER1
Mouse, Rat, Human
ELISA WB
Unconjugated
100µg 1mg/ml  $755.00

PER1 Antibody (C-Terminus) LS-C17242
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA WB
Unconjugated
100µl  $725.00

PER1 Antibody (aa1156-1183) LS-C323937
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA WB
Unconjugated
200µl  $530.00

PER1 Antibody (aa788-905, clone 2715C2) LS-C342466
Mouse Monoclonal [clone 2715C2] (IgG1) to Human PER1
Human
DB WB
Unconjugated
100µg 0.1mg/ml  $375.00
Western blot analysis of immunized recombinant protein, using anti-PER1 monoclonal antibody.
Western blot analysis of immunized recombinant protein, using anti-PER1 monoclonal antibody.

PER1 Antibody (Internal) LS-C17244
Chicken Polyclonal (IgY) to Mouse PER1
Mouse
ELISA WB
Unconjugated
100µl  $725.00
Showing 1-25 of 50 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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