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Unfortunately, the antibody (ID:91291) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PER1

period circadian clock 1

Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. Regulates circadian target genes expression at post-transcriptional levels, but may not be required for the repression at transcriptional level. Controls PER2 protein decay. Represses CRY2 preventing its repression on CLOCK/ARNTL target genes such as FXYD5 and SCNN1A in kidney and PPARA in liver. Besides its involvement in the maintenance of the circadian clock, has an important function in the regulation of several processes. Participates in the repression of glucocorticoid receptor NR3C1/GR-induced transcriptional activity by reducing the association of NR3C1/GR to glucocorticoid response elements (GREs) by ARNTL:CLOCK. Plays a role in the modulation of the neuroinflammatory state via the regulation of inflammatory mediators release, such as CCL2 and IL6. In spinal astrocytes, negatively regulates the MAPK14/p38 and MAPK8/JNK MAPK cascades as well as the subsequent activation of NFkappaB. Coordinately regulates the expression of multiple genes that are involved in the regulation of renal sodium reabsorption. Can act as gene expression activator in a gene and tissue specific manner, in kidney enhances WNK1 and SLC12A3 expression in collaboration with CLOCK. Modulates hair follicle cycling. Represses the CLOCK-ARNTL/BMAL1 induced transcription of BHLHE40/DEC1.

Gene Name: period circadian clock 1
Synonyms: PER1, HPER, HPER1, KIAA0482, Period circadian clock 1, Period, drosophila, homolog of, RIGUI, PER, Period (Drosophila) homolog 1, Period homolog 1 (Drosophila)
Target Sequences: NM_002616 NP_002607.2 O15534

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
PER1 Rabbit IgG Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus
1
PER1 Rabbit IgG Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus No Primary
Anti-PER1 Antibody (C-Terminus) LS-C17237
Rabbit Polyclonal (IgG) to Drosophila PER1
Drosophila
Western blot, ELISA
Unconjugated
PER1 Rabbit Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus
1
PER1 Rabbit Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus No Primary
Anti-PER1 Antibody (C-Terminus) LS-C17238
Rabbit Polyclonal to Drosophila PER1
Drosophila
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Monkey, Mouse, Bat, Hamster, Pig, Sheep IHC-P, IHC-Fr, ICC, IF, WB
1
PER1 Rabbit IgG Polyclonal Unconjugated Human, Chimpanzee, Monkey, Mouse, Bat, Hamster, Pig, Sheep IHC-P, IHC-Fr, ICC, IF, WB No Primary
Anti-PER1 Antibody LS-C355592
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PER1
Human, Chimpanzee, Monkey, Mouse, Bat, Hamster, Pig, Sheep
IHC - Paraffin, IHC - Frozen, ICC, Immunofluorescence, Western blot
Unconjugated
PER1 Rabbit Polyclonal Unconjugated Mouse, Human, Bovine, Dog, Horse, Pig IHC-P aa30-80
1
PER1 Rabbit Polyclonal Unconjugated Mouse, Human, Bovine, Dog, Horse, Pig IHC-P aa30-80 No Primary
Anti-PER1 Antibody (aa30-80) LS-C148631
Immunohistochemistry Image
Rabbit Polyclonal to Mouse PER1
Mouse, Human, Bovine, Dog, Horse, Pig
IHC - Paraffin
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated Mouse IHC, IF, WB, ELISA Internal
1
PER1 Rabbit IgG Polyclonal Unconjugated Mouse IHC, IF, WB, ELISA Internal No Primary
Anti-PER1 Antibody (Internal) LS-C17243
Rabbit Polyclonal (IgG) to Mouse PER1
Mouse
IHC, Immunofluorescence, Western blot, ELISA
Unconjugated
PER1 Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Rat, Guinea pig IHC-P, WB,WB,WB,WB N-Terminus
4
PER1 Rabbit Polyclonal Unconjugated Human, Rat, Guinea pig IHC-P, WB N-Terminus No Primary Available
Anti-PER1 Antibody (N-Terminus) IHC-plus™ LS-B14003
Immunohistochemistry - Paraffin Image
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Rat, Guinea pig
IHC - Paraffin, Western blot
Unconjugated
PER1 Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Rat, Guinea pig WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, HRP) LS-C430655
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Rat, Guinea pig
Western blot
HRP Conjugated
PER1 Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Rat, Guinea pig WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, Biotin) LS-C430653
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Rat, Guinea pig
Western blot
Biotin Conjugated
PER1 Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Rat, Guinea pig WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, FITC) LS-C430654
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Rat, Guinea pig
Western blot
FITC Conjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB
1
PER1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat IHC, WB No Primary
Anti-PER1 Antibody LS-C409984
Immunohistochemistry Image
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PER1
Human, Mouse, Rat
IHC, Western blot
Unconjugated
PER1 Rabbit IgG Polyclonal FITC Conjugated Human ICC, WB, ELISA aa208-414
1
PER1 Rabbit IgG Polyclonal FITC Conjugated Human ICC, WB, ELISA aa208-414 No Primary
Anti-PER1 Antibody (aa208-414, FITC) LS-C425142
Rabbit Polyclonal (IgG) to Human PER1
Human
ICC, Western blot, ELISA
FITC Conjugated
PER1 Rabbit IgG Polyclonal Biotin Conjugated Human ICC, WB, ELISA aa208-414
1
PER1 Rabbit IgG Polyclonal Biotin Conjugated Human ICC, WB, ELISA aa208-414 No Primary
Anti-PER1 Antibody (aa208-414, Biotin) LS-C425140
Rabbit Polyclonal (IgG) to Human PER1
Human
ICC, Western blot, ELISA
Biotin Conjugated
PER1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human IHC, ELISA,ELISA,ELISA,ELISA
4
PER1 Rabbit IgG Polyclonal Unconjugated Human IHC, ELISA No Primary
Anti-PER1 Antibody LS-C502286
Immunohistochemistry Image
Rabbit Polyclonal (IgG) to Human PER1
Human
IHC, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal HRP Conjugated Human ELISA No Primary
Anti-PER1 Antibody (HRP) LS-C499521
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA
HRP Conjugated
PER1 Rabbit IgG Polyclonal Biotin Conjugated Human ELISA No Primary
Anti-PER1 Antibody (Biotin) LS-C499528
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA
Biotin Conjugated
PER1 Rabbit IgG Polyclonal FITC Conjugated Human ELISA No Primary
Anti-PER1 Antibody (FITC) LS-C499522
Rabbit Polyclonal (IgG) to Human PER1
Human
ELISA
FITC Conjugated
PER1 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA Internal
1
PER1 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA Internal No Primary
Anti-PER1 Antibody (Internal) LS-C17239
Rabbit Polyclonal (IgG) to Mouse PER1
Mouse
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated,HRP Conjugated, Azide-free,Biotin Conjugated,FITC Conjugated,PE Conjugated,AP Conjugated,APC Conjugated Human WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA,WB, ELISA aa1155-1183
7
PER1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa1155-1183 No Primary
Anti-PER1 Antibody (aa1155-1183) LS-C323937
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, Azide-free, HRP) LS-C266057
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
HRP Conjugated, Azide-free
PER1 Rabbit IgG Polyclonal Biotin Conjugated Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, Biotin) LS-C266055
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
Biotin Conjugated
PER1 Rabbit IgG Polyclonal FITC Conjugated Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, FITC) LS-C266056
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
FITC Conjugated
PER1 Rabbit IgG Polyclonal PE Conjugated Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, PE) LS-C266060
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
PE Conjugated
PER1 Rabbit IgG Polyclonal AP Conjugated Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, AP) LS-C266053
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
AP Conjugated
PER1 Rabbit IgG Polyclonal APC Conjugated Human WB, ELISA aa1156-1183 No Primary
Anti-PER1 Antibody (aa1156-1183, APC) LS-C266054
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
APC Conjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA C-Terminus
1
PER1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA C-Terminus No Primary
Anti-PER1 Antibody (C-Terminus) LS-C17242
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA C-Terminus
1
PER1 Rabbit IgG Polyclonal Unconjugated Human, Mouse, Rat WB, ELISA C-Terminus No Primary
Anti-PER1 Antibody (C-Terminus) LS-C17241
Rabbit Polyclonal (IgG) to Human PER1
Human, Mouse, Rat
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa208-414
1
PER1 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA aa208-414 No Primary
Anti-PER1 Antibody (aa208-414) LS-C373783
Western blot Image
Rabbit Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
Unconjugated
PER1 Mouse IgG1 Monoclonal 2715C2 Unconjugated Human WB, DB
1
PER1 Mouse IgG1 Monoclonal 2715C2 Unconjugated Human WB, DB No Primary
Anti-PER1 Antibody (clone 2715C2) LS-C342466
Western blot Image
Mouse Monoclonal [clone 2715C2] (IgG1) to Human PER1
Human
Western blot, Dot Blot
Unconjugated
PER1 Sheep IgG Polyclonal Unconjugated Human WB, ELISA
1
PER1 Sheep IgG Polyclonal Unconjugated Human WB, ELISA No Primary
Anti-PER1 Antibody LS-C79411
Sheep Polyclonal (IgG) to Human PER1
Human
Western blot, ELISA
Unconjugated
PER1 Chicken IgY Polyclonal Unconjugated Mouse WB, ELISA Internal
1
PER1 Chicken IgY Polyclonal Unconjugated Mouse WB, ELISA Internal No Primary
Anti-PER1 Antibody (Internal) LS-C17244
Chicken Polyclonal (IgY) to Mouse PER1
Mouse
Western blot, ELISA
Unconjugated
PER1 Rabbit IgG Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus
1
PER1 Rabbit IgG Polyclonal Unconjugated Drosophila WB, ELISA C-Terminus No Primary
Anti-PER1 Antibody (C-Terminus) LS-C17257
Rabbit Polyclonal (IgG) to Drosophila PER1
Drosophila
Western blot, ELISA
Unconjugated
PER1 Mouse IgG1 Monoclonal Unconjugated Human WB
1
PER1 Mouse IgG1 Monoclonal Unconjugated Human WB No Primary
Anti-PER1 Antibody LS-C79410
Mouse Monoclonal (IgG1) to Human PER1
Human
Western blot
Unconjugated
PER1 Mouse IgG1 Monoclonal Unconjugated Human WB
1
PER1 Mouse IgG1 Monoclonal Unconjugated Human WB No Primary
Anti-PER1 Antibody LS-C74252
Mouse Monoclonal (IgG1) to Human PER1
Human
Western blot
Unconjugated
PER1 Rabbit Polyclonal Unconjugated Human WB aa1000-1200
1
PER1 Rabbit Polyclonal Unconjugated Human WB aa1000-1200 No Primary
Anti-PER1 Antibody (aa1000-1200) LS-C358596
Rabbit Polyclonal to Human PER1
Human
Western blot
Unconjugated
PER1 Mouse IgG1 Monoclonal 2715C2 Unconjugated Human DB
1
PER1 Mouse IgG1 Monoclonal 2715C2 Unconjugated Human DB No Primary
Anti-PER1 Antibody (clone 2715C2) LS-C184421
Mouse Monoclonal [clone 2715C2] (IgG1) to Human PER1
Human
Dot Blot
Unconjugated
PER1 Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit WB,WB,WB,WB N-Terminus
4
PER1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit WB N-Terminus No Primary Available
Anti-PER1 Antibody (N-Terminus) LS-C187217
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit
Western blot
Unconjugated
PER1 Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, HRP) LS-C464236
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit
Western blot
HRP Conjugated
PER1 Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, Biotin) LS-C464234
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit
Western blot
Biotin Conjugated
PER1 Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit WB N-Terminus No Primary
Anti-PER1 Antibody (N-Terminus, FITC) LS-C464235
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Orangutan, Gibbon, Mouse, Rat, Bat, Guinea pig, Horse, Pig, Rabbit
Western blot
FITC Conjugated
PER1 Rabbit Polyclonal Unconjugated,HRP Conjugated,Biotin Conjugated,FITC Conjugated Human, Monkey, Rat, Bat, Guinea pig, Hamster WB,WB,WB,WB aa41-90
4
PER1 Rabbit Polyclonal Unconjugated Human, Monkey, Rat, Bat, Guinea pig, Hamster WB aa41-90 No Primary
Anti-PER1 Antibody (aa41-90) LS-C206128
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Monkey, Rat, Bat, Guinea pig, Hamster
Western blot
Unconjugated
PER1 Rabbit Polyclonal HRP Conjugated Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster WB aa41-90 No Primary
Anti-PER1 Antibody (aa41-90, HRP) LS-C479457
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster
Western blot
HRP Conjugated
PER1 Rabbit Polyclonal Biotin Conjugated Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster WB aa41-90 No Primary
Anti-PER1 Antibody (aa41-90, Biotin) LS-C479455
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster
Western blot
Biotin Conjugated
PER1 Rabbit Polyclonal FITC Conjugated Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster WB aa41-90 No Primary
Anti-PER1 Antibody (aa41-90, FITC) LS-C479456
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Chimpanzee, Gibbon, Monkey, Rat, Bat, Guinea pig, Hamster
Western blot
FITC Conjugated
PER1 Rabbit IgG Polyclonal Unconjugated Human, Monkey WB aa289-302
1
PER1 Rabbit IgG Polyclonal Unconjugated Human, Monkey WB aa289-302 No Primary
Anti-PER1 Antibody (aa289-302) LS-C313170
Western blot Image
Rabbit Polyclonal (IgG) to Human PER1
Human, Monkey
Western blot
Unconjugated
PER1 Rabbit Polyclonal Unconjugated Human WB aa1156-1183
1
PER1 Rabbit Polyclonal Unconjugated Human WB aa1156-1183 No Primary Available
Anti-PER1 Antibody (aa1156-1183) LS-C163521
Western blot Image
Rabbit Polyclonal to Human PER1
Human
Western blot
Unconjugated
PER1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Horse WB aa1150-1200
1
PER1 Rabbit Polyclonal Unconjugated Human, Mouse, Rat, Bovine, Horse WB aa1150-1200 No Primary
Anti-PER1 Antibody (aa1150-1200) LS-C148627
Western blot Image
Rabbit Polyclonal to Human PER1
Human, Mouse, Rat, Bovine, Horse
Western blot
Unconjugated
Target Corresponding Antibodies
PER1
1
PER1 Antibody Blocking Peptide - LS-E4479
LS-E4479
PER1
LS-C163521
PER1
1
PER1 Antibody Blocking Peptide - LS-E12083
LS-E12083
PER1
LS-B14003
PER1
1
PER1 Antibody Blocking Peptide - LS-E21164
LS-E21164
PER1
LS-C187217
Type Target Reactivity Sample Type
Sandwich PER1 Human Cell Lysates, Tissue Homogenates
1
Human PER1 ELISA Kit (Sandwich ELISA) - LS-F7944
 Image
 Image
Sandwich ELISA
96-Well Strip Plate
Human
0.313-20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
Type Target Tag Species Source Purified Biological Activity Known Endotoxin Level Animal-Free
Recombinant PER1 His + S Human E. coli
1
Human PER1 Protein (Recombinant His + S) - LS-G26164
E. coli Expression System
His + S
Lyophilized
26.8 kDa

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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