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PEPD / PROLIDASE

peptidase D

PEPD / PROLIDASE is a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: peptidase D
Family/Subfamily: Exopeptidase , Metallopeptidase M24B
Synonyms: PEPD, Aminoacyl-L-proline hydrolase, Imidodipeptidase, PRD, PROLIDASE, X-Pro dipeptidase, Xaa-Pro dipeptidase, Peptidase D, Proline dipeptidase
Target Sequences: NM_000285 NP_000276.2 P12955

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).