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PDZK1

PDZ domain containing 1

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.

Gene Name: PDZ domain containing 1
Synonyms: PDZK1, CAP70, CLAMP, NHERF-3, PDZD1, PDZ domain containing 1, NaPi-Cap1, NHERF3
Target Sequences: NM_002614 NP_002605.2 Q5T2W1

Publications (2)

1
Interaction with PDZK1 is required for expression of organic anion transporting protein 1A1 on the hepatocyte surface. Wang P, Wang JJ, Xiao Y, Murray JW, Novikoff PM, Angeletti RH, Orr GA, Lan D, Silver DL, Wolkoff AW. The Journal of biological chemistry. 2005 280:30143-9. [PubMed:15994332]
2
A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase. Robichaud JC, Francis GA, Vance DE. The Journal of biological chemistry. 2008 283:35496-506. [PubMed:18842588]

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Antibodies (31)
Primary (31)
PDZK1 (31)
Human (30)
Mouse (14)
Rat (9)
Bat (3)
Bovine (1)
Chimpanzee (6)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Orangutan (6)
Pig (3)
IHC (14)
IHC-P (6)
WB (29)
ELISA (13)
ICC (1)
IF (3)
IP (1)
Peptide-ELISA (1)
rabbit (28)
mouse (2)
goat (1)
Product Group
IHCPlus (4)
IgG (20)
IgG1,k (1)
IgG2b,k (1)
monoclonal mc (2)
polyclonal pc (29)
1C3-2B11 (1)
AT1A2 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (17)
aa196-224 (7)
N-Terminus (4)
aa80-129 (4)
C-Terminus (2)
aa 1-519 (1)
aa1-519 (1)
No (31)
PDZK1 Antibody - Anti-PDZK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDZK1 Mouse anti-Human Monoclonal (1C3-2B11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
PDZK1 Antibody - Anti-PDZK1 antibody IHC of human kidney cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDZK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Bovine, Human
IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
PDZK1 Antibody - Anti-PDZK1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PDZK1 Mouse anti-Human Monoclonal (AT1A2) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDZK1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PDZK1 Rabbit anti-Human Polyclonal (aa 1-519) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
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PDZK1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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PDZK1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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PDZK1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
PDZK1 Antibody - Immunochemical staining of human PDZK1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
50 µl/$317; 100 µl/$375; 200 µl/$473
PDZK1 Antibody - PDZK1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human kidney tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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PDZK1 Rabbit anti-Human Polyclonal (aa196-224) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
PDZK1 Antibody - 1:100 staining mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PDZK1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IF, WB
Unconjugated
100 µl/$649
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
PDZK1 Antibody - Western blot analysis of extracts of various cell lines.
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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PDZK1 Goat anti-Mouse Polyclonal (aa1-519) Antibody
Mouse, Rat
WB
Unconjugated
100 µg/$884
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PDZK1 Antibody - PDZK1 antibody Western blot of HepG2 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDZK1 Rabbit anti-Human Polyclonal (aa80-129) Antibody
Human
WB
Unconjugated
100 µl/$424
PDZK1 Antibody - PDZK1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDZK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
PDZK1 Antibody - Western blot analysis of PDZK1 expression in mouse kidney (A); mouse liver (B) whole cell lysates.
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PDZK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).