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PDZD3
PDZ domain containing 3
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).
| Gene Name: | PDZ domain containing 3 |
| Synonyms: | PDZD3, IKEPP, NHERF-4, PDZ domain containing 2, PDZK2, NaPi-Cap2, NHERF4, PDZ domain containing 3 |
| Target Sequences: | NM_024791 |
Publications (1)
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