PDK2

pyruvate dehydrogenase kinase, isozyme 2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

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Products

Antibodies (55)

Type

Primary (55)

Target

PDK2 (55)

Reactivity

Human (40)

Mouse (39)

Rat (16)

Bat (1)

Bovine (5)

Chimpanzee (3)

Gibbon (3)

Guinea pig (1)

Horse (1)

Monkey (8)

Orangutan (3)

Pig (1)

Primate (1)

Sheep (1)

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Application

IHC (33)

IHC-P (11)

WB (54)

Flo (7)

ELISA (33)

ICC (1)

IF (1)

IP (1)

Peptide-ELISA (3)

Host

rabbit (45)

mouse (10)

Product Group

IHCPlus (3)

Isotype

IgG (31)

IgG1,k (7)

IgG2a,k (2)

IgG2b (1)

Clonality

monoclonal mc (10)

polyclonal pc (45)

Clone

180CT10.2.3 (6)

2G1 (1)

3F2D7 (1)

5F8 (1)

Format

APC (1)

APC Conjugated (5)

Azide-free (4)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (5)

Unconjugated (25)

Epitope

aa155-379 (8)

aa378-407 (7)

aa78-107 (7)

aa251-300 (4)

230-310 aa, Internal (1)

Arg291 (1)

Internal (1)

aa128-407 (1)

aa242-291 (1)

aa260-309 (1)

aa379-392 (1)

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Publications

No (54)

Yes (1)

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IHC-plus™ PDK2 Antibody (clone 2G1) LS-B5412

(4.0) Rating

Antibody:

PDK2 Mouse anti-Human Monoclonal (2G1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ PDK2 Antibody (clone 5F8) LS-B5413

(4.0) Rating

Antibody:

PDK2 Mouse anti-Human Monoclonal (5F8) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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PDK2 Antibody (aa260-309) LS-C120281

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa260-309) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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PDK2 Antibody (aa379-392) LS-C313126

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa379-392) Antibody

Reactivity:

Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PDK2 Antibody (aa251-300) LS-B5583

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa251-300) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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PDK2 Antibody LS-C323915

Antibody:

PDK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PDK2 Antibody (Biotin) LS-C209012

Antibody:

PDK2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PDK2 Antibody (FITC) LS-C207429

Antibody:

PDK2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PDK2 Antibody (APC) LS-C209010

Antibody:

PDK2 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PDK2 Antibody (Azide-free, HRP) LS-C207430

Antibody:

PDK2 Rabbit anti-Human Polyclonal (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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PDK2 Antibody (PE) LS-C207431

Antibody:

PDK2 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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PDK2 Antibody (aa128-407) LS-C377454

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa128-407) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PDK2 Antibody LS-C753149

Antibody:

PDK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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PDK2 Antibody (aa78-107) LS-C164523

Antibody:

PDK2 Rabbit anti-Mouse Polyclonal (aa78-107) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PDK2 Antibody (aa78-107) LS-C323913

Antibody:

PDK2 Rabbit anti-Mouse Polyclonal (aa78-107) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PDK2 Antibody (aa78-107, Biotin) LS-C207440

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa78-107) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PDK2 Antibody (aa78-107, APC) LS-C207439

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa78-107) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• APC

• Unconjugated
• Biotin
• APC

Select

PDK2 Antibody LS-C402512

Antibody:

PDK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PDK2 Antibody (aa378-407) LS-C323912

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa378-407) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PDK2 Antibody (aa378-407, FITC) LS-C207435

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa378-407) (FITC) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PDK2 Antibody (aa378-407, PE) LS-C207437

Antibody:

PDK2 Rabbit anti-Human Polyclonal (aa378-407) (PE) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC
• PE

• Unconjugated
• FITC
• PE

Select

PDK2 Antibody (230-310 aa, Internal) LS-C385415

Antibody:

PDK2 Rabbit anti-Human Polyclonal (230-310 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PDK2 Antibody (clone 3F2D7) LS-C669205

Antibody:

PDK2 Mouse anti-Human Monoclonal (3F2D7) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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PDK2 Antibody (clone 180CT10.2.3) LS-C319190

Antibody:

PDK2 Mouse anti-Mouse Monoclonal (180CT10.2.3) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PDK2 Antibody LS-C805282

Antibody:

PDK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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