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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
Protein Family And Group
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PDK2

pyruvate dehydrogenase kinase, isozyme 2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Gene Name: pyruvate dehydrogenase kinase, isozyme 2
Family/Subfamily: Protein Kinase , PDK/BCKDK
Synonyms: PDK2, PDHK2, PDHKII
Target Sequences: NM_002611 NP_002602.2 Q15119

Publications (4)

1
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. The Journal of biological chemistry. 2006 281:39897-906. (WB, ChrIP; Rat) [PubMed:17079227] Related Antibodies: LS-C98957.
2
Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure. Richards JG, Sardella BA, Schulte PM. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R979-90. [PubMed:18579651] Related Antibodies: LS-C98957.
3
Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia. Speers-Roesch B, Sandblom E, Lau GY, Farrell AP, Richards JG. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 298:R104-19. [PubMed:19864337] Related Antibodies: LS-C98957.
4
The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity. Love LK, LeBlanc PJ, Inglis JG, Bradley NS, Choptiany J, Heigenhauser GJ, Peters SJ. Journal of applied physiology (Bethesda, Md. : 1985). 2011 111:427-34. [PubMed:21596918] Related Antibodies: LS-C98957.
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Viewing 1-25 of 59 items
PDK2 Antibody - Anti-PDK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 2G1] (IgG2a,k) to Human PDK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
PDK2 Antibody - Anti-PDK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 5F8] (IgG2a,k) to Human PDK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
PDK2 Antibody - Anti-PDK2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PDK2
Bovine, Human
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
PDK2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human PDK2
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
PDK2 Antibody - Western blot analysis of lysates from HepG2 cells, using PDK2 Antibody. The lane on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
PDK2 Antibody - PDK2 antibody. IHC(P): Human Breast Cancer Tissue.
Select
Rabbit Polyclonal to Human PDK2
Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl   $740.00
PDK2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $335.00
PDK2 Antibody - Mouse Pdk2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Mouse PDK2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Mouse PDK2
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
PDK2 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using PDK2 Polyclonal Antibody at dilution of 1:40.
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.5mg/ml   $205.00; 60µl   0.5mg/ml   $235.00; 120µl   0.5mg/ml   $295.00; 200µl   0.5mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
PDK2 Antibody - Western blot of PDK2 antibody
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
PDK2 Antibody - Staining HepG2 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Mouse Monoclonal [clone 3F2D7] (IgG2b) to Human PDK2
Human
ELISA, Flo
Unconjugated
100µl   $365.00
Select
Mouse Monoclonal [clone 180CT10.2.3] (IgG1,k) to Mouse PDK2
Mouse
ELISA, WB
Unconjugated
200µl   $590.00

Viewing 1-25 of 59 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).