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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PDK2

pyruvate dehydrogenase kinase, isozyme 2

Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.

Gene Name: pyruvate dehydrogenase kinase, isozyme 2
Family/Subfamily: Protein Kinase , PDK/BCKDK
Synonyms: PDK2, PDHK2, PDHKII
Target Sequences: NM_002611 NP_002602.2 Q15119

Publications (4)

1
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. Zhang Y, Ma K, Sadana P, Chowdhury F, Gaillard S, Wang F, McDonnell DP, Unterman TG, Elam MB, Park EA. The Journal of biological chemistry. 2006 281:39897-906. (WB, ChrIP; Rat) [PubMed:17079227] Related Antibodies: LS-C98957.
2
Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure. Richards JG, Sardella BA, Schulte PM. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 295:R979-90. [PubMed:18579651] Related Antibodies: LS-C98957.
3
Effects of environmental hypoxia on cardiac energy metabolism and performance in tilapia. Speers-Roesch B, Sandblom E, Lau GY, Farrell AP, Richards JG. American journal of physiology. Regulatory, integrative and comparative physiology. 2010 298:R104-19. [PubMed:19864337] Related Antibodies: LS-C98957.
4
The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity. Love LK, LeBlanc PJ, Inglis JG, Bradley NS, Choptiany J, Heigenhauser GJ, Peters SJ. Journal of applied physiology (Bethesda, Md. : 1985). 2011 111:427-34. [PubMed:21596918] Related Antibodies: LS-C98957.
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Filtered by: None
Target
PDK2 (59)
Reactivity
Human (43)
Mouse (42)
Rat (17)
Bat (1)
Bovine (6)
Chimpanzee (3)
Gibbon (3)
Guinea pig (1)
Horse (1)
Monkey (9)
Orangutan (3)
Pig (1)
Primate (1)
Sheep (1)
Application
IHC (36)
IHC-P (11)
WB (58)
Flo (8)
ELISA (38)
ICC (1)
IF (1)
IP (1)
Peptide-ELISA (2)
Host
rabbit (48)
mouse (11)
Isotype
IgG (34)
IgG1,k (8)
IgG2a,k (2)
IgG2b (1)
Clonality
monoclonal mc (11)
polyclonal pc (48)
Clone
180CT10.2.3 (7)
2G1 (1)
3F2D7 (1)
5F8 (1)
Format
AP Conjugated (4)
APC (1)
APC Conjugated (5)
Azide-free (4)
Biotin Conjugated (6)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (5)
Unconjugated (25)
Epitope
aa155-379 (8)
aa378-407 (8)
aa78-107 (8)
aa251-300 (4)
230-310 aa, Internal (1)
Arg291 (1)
Internal (1)
aa128-407 (1)
aa242-291 (1)
aa260-309 (1)
aa379-392 (1)
Publications
No (58)
Yes (1)
Showing 1-25 of 59 results

IHC-plus™ PDK2 Antibody (clone 2G1) LS-B5412
Mouse Monoclonal [clone 2G1] (IgG2a,k) to Human PDK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-PDK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PDK2 monoclonal antibody clone 2G1 Western blot of PDK2 expression in U-2 OS.

PDK2 Antibody (aa378-407) LS-C98957
Publications (4)
Publications (4)
Rabbit Polyclonal to Human PDK2
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of PDK2 Antibody in mouse intestine tissue lysate (35 ug/lane). PDK2 (arrow) was detected using the purified antibody.

IHC-plus™ PDK2 Antibody (clone 5F8) LS-B5413
Mouse Monoclonal [clone 5F8] (IgG2a,k) to Human PDK2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $495.00
Anti-PDK2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
PDK2 monoclonal antibody clone 5F8. Western blot of PDK2 expression in 293.

PDK2 Antibody (aa260-309) LS-C120281
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of lysates from HepG2 cells, using PDK2 Antibody. The lane on the right is blocked with the synthesized peptide.

PDK2 Antibody (aa379-392) LS-C313126
Rabbit Polyclonal to Human PDK2
Mouse, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
PDK2 antibody. IHC(P): Human Breast Cancer Tissue.
PDK2 antibody. IHC(P): Rat Brain Tissue.

PDK2 Antibody LS-C323915
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
Unconjugated
200µl  $590.00

PDK2 Antibody (Biotin) LS-C209012
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl  $740.00

PDK2 Antibody (FITC) LS-C207429
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

PDK2 Antibody (APC) LS-C209010
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl  $740.00

PDK2 Antibody (AP) LS-C209008
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
AP Conjugated
200µl  $740.00

PDK2 Antibody (Azide-free, HRP) LS-C207430
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200µl  $740.00

PDK2 Antibody (PE) LS-C207431
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, Flo, IHC, WB
PE Conjugated
200µl  $740.00

PDK2 Antibody (aa128-407) LS-C377454
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human skeletal muscle using antibody at 1:100 dilution.

IHC-plus™ PDK2 Antibody (aa251-300) LS-B5583
Rabbit Polyclonal (IgG) to Human PDK2
Bovine, Human
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-PDK2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
PDK2 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK2 Antibody LS-C753149
Rabbit Polyclonal (IgG) to Human PDK2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg  $335.00

PDK2 Antibody (aa78-107) LS-C164523
Rabbit Polyclonal to Mouse PDK2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Mouse Pdk2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse heart tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Mouse Pdk2 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The Pdk2 antibody detected the Pdk2 protein (arrow).

PDK2 Antibody (aa78-107) LS-C323913
Rabbit Polyclonal (IgG) to Mouse PDK2
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl  $590.00

PDK2 Antibody (aa78-107, FITC) LS-C207441
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl  $740.00

PDK2 Antibody (aa78-107, PE) LS-C207443
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl  $740.00

PDK2 Antibody LS-C402512
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human liver cancer using PDK2 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human lung cancer using PDK2 Polyclonal Antibody at dilution of 1:40.

PDK2 Antibody (aa378-407) LS-C323912
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
200µl  $590.00

PDK2 Antibody (230-310 aa, Internal) LS-C385415
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of PDK2 antibody

PDK2 Antibody LS-C805282
Rabbit Polyclonal (IgG) to Human PDK2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image

PDK2 Antibody (clone 180CT10.2.3) LS-C319190
Mouse Monoclonal [clone 180CT10.2.3] (IgG1,k) to Mouse PDK2
Mouse
ELISA, WB
Unconjugated
200µl  $590.00

PDK2 Antibody (clone 3F2D7) LS-C669205
Mouse Monoclonal [clone 3F2D7] (IgG2b) to Human PDK2
Human
ELISA, Flo
Unconjugated
0.1mg  $365.00
Showing 1-25 of 59 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).