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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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PDK1
pyruvate dehydrogenase kinase, isozyme 1
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
| Gene Name: | pyruvate dehydrogenase kinase, isozyme 1 |
| Family/Subfamily: | Protein Kinase , PDK/BCKDK |
| Synonyms: | PDK1, PDHK, PDH kinase 1, PDHK1 |
| Target Sequences: | NM_002610 NP_002601.1 Q15118 |
Publications (3)
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