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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PDK1

pyruvate dehydrogenase kinase, isozyme 1

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

Gene Name: pyruvate dehydrogenase kinase, isozyme 1
Family/Subfamily: Protein Kinase , PDK/BCKDK
Synonyms: PDK1, PDHK, PDH kinase 1, PDHK1
Target Sequences: NM_002610 NP_002601.1 Q15118

Publications (2)

1
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Cell. 2011 145:732-44. (WB, ChrIP; Human) [PubMed:21620138] [PMC:PMC3130564]
2
Caffeic acid phenethyl ester causes p21 induction, Akt signaling reduction, and growth inhibition in PC-3 human prostate cancer cells. Lin HP, Jiang SS, Chuu CP. PloS one. 2012 7:e31286. [PubMed:22347457] [PMC:PMC3274546]

Filtered By: None
Target
PDK1 (65)
Reactivity
Human (55)
Mouse (40)
Rat (26)
Bat (1)
Bovine (5)
Chimpanzee (3)
Dog (6)
Gibbon (3)
Guinea pig (1)
Hamster (1)
Horse (5)
Monkey (10)
Pig (3)
Rabbit (2)
Sheep (1)
Application
IHC (37)
IHC-P (16)
WB (59)
Flo (1)
ELISA (16)
IF (1)
IP (4)
Peptide-ELISA (1)
Host
rabbit (61)
mouse (3)
goat (1)
Isotype
IgG (44)
IgG1 (1)
IgG2a (1)
IgG2b,k (1)
Clonality
monoclonal mc (4)
polyclonal pc (61)
Clone
3B7 (1)
4A11 (1)
Format
AP Conjugated (1)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (9)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (5)
PE Conjugated (3)
Unconjugated (27)
Epitope
aa172-399 (10)
aa233-430 (10)
aa1-30 (8)
C-Terminus (7)
Internal (6)
aa287-336 (4)
80-160 aa, Internal (1)
aa123-133 (1)
aa300-400 (1)
aa350-436 (1)
aa408-421 (1)
aa421-436 (1)
aa542 (1)
Publications
No (65)
Showing 1-25 of 65 results

PDK1 Antibody (aa300-400) IHC-plus™ LS-B689
Rabbit Polyclonal to Human PDK1
Mouse, Human
IHC IHC-P WB
Unconjugated
100µl 0.5mg/ml  $425.00
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (Internal, Biotin) LS-C141008
Rabbit Polyclonal to Human PDK1
Human
IHC IHC-P WB
Biotin Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (Internal, DY488) LS-C141010
Rabbit Polyclonal to Human PDK1
Mouse, Human
IHC IHC-P WB
DY488 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (Internal, DY650) LS-C141009
Rabbit Polyclonal to Human PDK1
Mouse, Human
IHC IHC-P WB
DY650 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (Internal, DY550) LS-C141012
Rabbit Polyclonal to Human PDK1
Mouse, Human
IHC IHC-P WB
DY550 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (aa421-436) LS-C26009
Rabbit Polyclonal (IgG) to Human PDK1
Mouse, Dog, Rat, Pig, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $385.00; 200µg  $515.00

PDK1 Antibody (aa350-436) IHC-plus™ LS-B1733
Rabbit Polyclonal to Human PDK1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µl 1.42mg/ml  $425.00
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (C-Terminus, Biotin) LS-C141003
Rabbit Polyclonal to Human PDK1
Human
IHC IHC-P WB
Biotin Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (C-Terminus, DY650) LS-C141004
Rabbit Polyclonal to Human PDK1
Mouse, Rat, Human
IHC IHC-P WB
DY650 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (C-Terminus, DY488) LS-C141005
Rabbit Polyclonal to Human PDK1
Mouse, Rat, Human
IHC IHC-P WB
DY488 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (C-Terminus, DY550) LS-C141007
Rabbit Polyclonal to Human PDK1
Mouse, Rat, Human
IHC IHC-P WB
DY550 Conjugated
100µl  $365.00
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-PDK1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of PDK1 in human heart lysate using antibody at 2 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (clone 4A11) IHC-plus™ LS-B13567
Mouse Monoclonal [clone 4A11] (IgG1) to Human PDK1
Human
ELISA Flo IF IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence of HELA cells using PDK1 mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescence of HELA cells using PDK1 mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

PDK1 Antibody IHC-plus™ LS-B3690
Rabbit Polyclonal to Human PDK1
Rabbit, Mouse, Dog, Rat, Pig, Human, Monkey
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-PDK1 antibody IHC of human skeletal muscle. human. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of PDK1: Lane 1: MWM, Lane 2: HeLa, Lane 3: Rat Brain, Lane 4: Mouse Brain, Lane 5: Vero, Lane 6: ESK-4, Lane 7: RK-13, Lane 8: MDCK
Anti-PDK1 antibody IHC of human skeletal muscle. human. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of PDK1: Lane 1: MWM, Lane 2: HeLa, Lane 3: Rat Brain, Lane 4: Mouse Brain, Lane 5: Vero, Lane 6: ESK-4, Lane 7: RK-13, Lane 8: MDCK

PDK1 Antibody LS-C131340
Rabbit Monoclonal (IgG) to Human PDK1
Mouse, Rat, Human, Monkey
IP WB
Unconjugated
20µl  $395.00; 100µl  $530.00

PDK1 Antibody LS-C754902
Rabbit Polyclonal (IgG) to Human PDK1
Human
ELISA IHC IP WB
Unconjugated
100µg  $335.00

PDK1 Antibody LS-C754904
Rabbit Polyclonal (IgG) to Human PDK1
Human
ELISA IHC IP WB
Unconjugated
100µg  $355.00

PDK1 Antibody LS-C662518
Rabbit Polyclonal to Human PDK1
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $325.00
Immunohistochemistry - Anti-PDK1 Picoband antibody
Western blot - Anti-PDK1 Picoband antibody
Immunohistochemistry - Anti-PDK1 Picoband antibody
Western blot - Anti-PDK1 Picoband antibody

PDK1 Antibody LS-C671875
Rabbit Polyclonal (IgG) to Human PDK1
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image of paraffin-embedded human liver cancer at a dilution of 1:100
Positive Western Blot detected in Mouse kidney tissue. All lanes: PDK1 antibody at 2.8 µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50, 52 KDa. Observed band size: 50 KDa
Immunohistochemistry image of paraffin-embedded human liver cancer at a dilution of 1:100
Positive Western Blot detected in Mouse kidney tissue. All lanes: PDK1 antibody at 2.8 µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50, 52 KDa. Observed band size: 50 KDa

PDK1 Antibody (aa542) LS-C190234
Rabbit Polyclonal (IgG) to Human PDK1
Mouse, Rat, Human
IHC IP WB
Unconjugated
100µg 0.5mg/ml  $495.00

PDK1 Antibody (aa172-399) LS-C296164
Rabbit Polyclonal (IgG) to Mouse PDK1
Mouse
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $545.00; 10ml 0.5mg/ml  $2,160.00
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (aa172-399, Biotin) LS-C687394
Rabbit Polyclonal (IgG) to Mouse PDK1
Mouse
IHC WB
Biotin Conjugated
20µl  $205.00; 100µl  $275.00; 200µl  $315.00; 1ml  $590.00; 10ml  $2,370.00
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

PDK1 Antibody (aa408-421) LS-C313124
Rabbit Polyclonal to Human PDK1
Rabbit, Guinea pig, Sheep, Bovine, Pig, Human, Monkey
IHC IHC-P WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
PDK1 antibody. IHC(P):Human Prostatic Cancer Tissue.
WB of PDK1 antibody. Lane 1: Rat Heart Tissue Lysate. Lane 2: Rat Skeletal Muscle Tissue Lysate. Lane 3: HELA Cell Lysate. Lane 4: M231 Cell Lysate. Lane 5: COLO320 Cell Lysate. Lane 6: SW620 Cell Lysate.
PDK1 antibody. IHC(P):Human Prostatic Cancer Tissue.
WB of PDK1 antibody. Lane 1: Rat Heart Tissue Lysate. Lane 2: Rat Skeletal Muscle Tissue Lysate. Lane 3: HELA Cell Lysate. Lane 4: M231 Cell Lysate. Lane 5: COLO320 Cell Lysate. Lane 6: SW620 Cell Lysate.

PDK1 Antibody (C-Terminus) LS-C137080
Rabbit Polyclonal (IgG) to Human PDK1
Mouse, Rat, Human
ELISA IHC
Unconjugated
100µl  $255.00
Immunohistochemistry Image
Immunohistochemistry Image

PDK1 Antibody (C-Terminus) LS-C137079
Rabbit Polyclonal (IgG) to Human PDK1
Human
ELISA IHC
Unconjugated
100µl  $255.00
Immunohistochemistry Image
Immunohistochemistry Image

PDK1 Antibody (aa233-430) LS-C296165
Rabbit Polyclonal (IgG) to Human PDK1
Rat, Human
IHC WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of recombinant PDK1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-25 of 65 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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