PDGFRB / PDGFR Beta

platelet-derived growth factor receptor, beta polypeptide

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

PDGFRB / PDGFR Beta (12)

Publications

No (12)

Tag

6His, C-terminus (2)

DDK (Flag)-His, C-terminus (1)

DDK,C-terminus (1)

Fc (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (1)

Rat (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (3)

Human Cells (4)

Mammalian Cells (1)

Sf9 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (5)

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Mouse PDGFRB / PDGFR Beta Protein (Recombinant His, N-Terminal) (Val337-Pro583) - LS-G14711

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

32.0 kDa

Price:

10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142

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Human PDGFRB / PDGFR Beta Protein (Recombinant DDK,C-terminus) - LS-G142387

Source:

Sf9 Cells

Tag:

DDK,C-terminus

Molecular Weight:

56.2 kDa

Price:

20 µg/$677

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Human PDGFRB / PDGFR Beta Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142201

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

59 kDa

Price:

20 µg/$1,107

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Human PDGFRB / PDGFR Beta Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68032

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

123.8 kDa

Price:

20 µg/$1,107

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Human PDGFRB / PDGFR Beta Protein (Recombinant GST, N-terminus) (aa33-133) - LS-G59548

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PDGFRB / PDGFR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81267

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

123.8 kDa

Price:

20 µg/$150

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Human PDGFRB / PDGFR Beta Protein (Recombinant His) (Met1-Lys531) - LS-G98636

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.6 kDa

Price:

100 µg/$661; 1 mg/$3,499

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PDGFRB / PDGFR Beta Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99805

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

123.8 kDa

Price:

100 µg/$494

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Rat PDGFRB / PDGFR Beta Protein (Recombinant Fc) (Met1-Lys530) - LS-G98455

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.2 kDa

Price:

100 µg/$661

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Human PDGFRB / PDGFR Beta Protein (Recombinant 6His, C-terminus) (Leu33-Phe530) - LS-G138731

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.2 kDa

Price:

10 µg/$248; 50 µg/$317

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Human PDGFRB / PDGFR Beta Protein (Recombinant 6His, C-terminus) (Leu33-Phe530) - LS-G38902

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.17kD

Price:

10 µg/$248; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627

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Rat PDGFRB / PDGFR Beta Protein (Recombinant His) (Met1-Lys530) - LS-G98457

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.6 kDa

Price:

100 µg/$502

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