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Unfortunately, the antibody (ID:155969) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PDGFRB / PDGFR Beta

platelet-derived growth factor receptor, beta polypeptide

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

Gene Name: platelet-derived growth factor receptor, beta polypeptide
Family/Subfamily: Protein Kinase , PDGF Receptor
Synonyms: PDGFRB, CD140B, Beta pdfgr, Beta type PDGFR, BPDGFR, CD140b antigen, IBGC4, JTK12, PDGF-beta R, PDGF-R-beta, PDGFR, PDGFRbeta, PDGF receptor beta, PDGF-R, PDGFbetaR, PDGFR Beta, PDGFR-1, PDGFR-beta, BetaPDGFR, Pdgf beta-receptor, PDGFR1, PDGFRB/CEV14 fusion gene
Target Sequences: NM_002609 NP_002600.1 P09619

Publications (5)

1
Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons. Beazely MA, Lim A, Li H, Trepanier C, Chen X, Sidhu B, Macdonald JF. The Journal of biological chemistry. 2009 284:8054-63. (ICC, IP) [PubMed:19106110] [PMC:PMC2658099]
2
Vascular pathology in dermatomyositis and anatomic relations to myopathology. Pestronk A, Schmidt RE, Choksi R. Muscle & nerve. 2010 42:53-61. (IHC; Human) [Full Text Article] [PubMed:20544925] Related Antibodies: LS-C9623.
3
NG2 proteoglycan-dependent recruitment of tumor macrophages promotes pericyte-endothelial cell interactions required for brain tumor vascularization. Yotsumoto F, You WK, Cejudo-Martin P, Kucharova K, Sakimura K, Stallcup WB. Oncoimmunology. 2015 4:e1001204. (IHC; Mouse) [Full Text Article] [PubMed:26137396] [PMC:PMC4485789]
4
Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm. Vorkapic E, Dugic E, Vikingsson S, Roy J, Mäyränpää MI, Eriksson P, Wågsäter D. Atherosclerosis. 2016 249:101-9. (WB; Human) [Full Text Article] [PubMed:27085160] Related Antibodies: LS-C178098.
5
PDGFR- beta (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo. Yuan SM, Guo Y, Zhou XJ, Shen WM, Chen HN. International journal of clinical and experimental pathology. 7:2861-70. [Full Text Article] [PubMed:25031705] [PMC:PMC4097281] Related Antibodies: LS-C38281.
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Filtered By: None
Target
pdgfrb-pdgfr-beta (161)
Reactivity
Human (135)
Mouse (80)
Rat (34)
Baboon (2)
Bat (1)
Bovine (11)
Cynomolgus (1)
Dog (4)
Horse (1)
Monkey (17)
Pig (10)
Rabbit (11)
Rhesus monkey (1)
Application
IHC (72)
IHC-Fr (5)
IHC-P (39)
WB (105)
Flo (22)
ELISA (54)
ICC (4)
IF (17)
IP (20)
Neut (1)
Peptide-ELISA (9)
Host
rabbit (115)
mouse (35)
rat (4)
sheep (7)
Isotype
IgG (82)
IgG1 (18)
IgG1,k (10)
IgG2a (1)
IgG2a,k (5)
IgG2b (1)
Clonality
monoclonal mc (46)
polyclonal pc (115)
Clone
1.A.33 (1)
18A2 (4)
1A2 (1)
1D1 (1)
1D2 (1)
1E8 (1)
1G9 (1)
22B1 (1)
275CT1 (7)
2G7B7 (1)
3B5 (1)
42G12 (1)
4C12 (1)
APB5 (4)
PR7212 (5)
Format
AP Conjugated (7)
APC (1)
APC Conjugated (11)
Azide-free (6)
Biotin Conjugated (11)
CF Conjugated (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (12)
HRP Conjugated (9)
PE Conjugated (12)
Ready-to-Use (1)
Unconjugated (96)
Epitope
Extracellular Domain (19)
aa337-583 (10)
aa40-72 (8)
pTyr751 (7)
pTyr740 (4)
C-Terminus (2)
pTyr1009 (2)
pTyr1021 (2)
pTyr771 (2)
Asp1003 (1)
Gly1017 (1)
Internal (1)
Lys745 (1)
Tyr1009 (1)
Tyr1021 (1)
Tyr579 (1)
Tyr716 (1)
Tyr740 (1)
Tyr751 (1)
Tyr771 (1)
Tyr857 (1)
aa1013-1025 (1)
aa1027-1061 (1)
aa1028-1042 (1)
aa1095-1106 (1)
aa680-760 (1)
aa690-770 (1)
aa710-790 (1)
aa711-760 (1)
aa718-767 (1)
aa950-1030 (1)
aa960-1040 (1)
aa981-1030 (1)
aa991-1040 (1)
pTyr579 (1)
Publications
No (158)
Yes (3)
Showing 1-25 out of 161 results
PDGFRB / PDGFR Beta Antibody (Extracellular Domain) IHC-plus™ LS-A9414
Anti-PDGFRB antibody LS-A9414 IHC of human kidney, glomerulus and renal tubular epithelium in cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Rabbit, Bovine, Pig, Human, Monkey
IHC IHC-P
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone 42G12) IHC-plus™ LS-B3667
Anti-PDGFRB antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3667 concentration 20 ug/ml.
Anti-PDGFRB antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3667 concentration 20 ug/ml.

Mouse Monoclonal [clone 42G12] (IgG1) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (Extracellular Domain) IHC-plus™ LS-A9413
Anti-PDGFRB antibody LS-A9413 IHC of human kidney, renal tubular epithelium in cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Human
IHC IHC-P
Unconjugated
PDGFRB / PDGFR Beta Antibody (phospho-Tyr751) LS-C9623

Mouse Monoclonal (IgG2b) to Human PDGFRB / PDGFR Beta
Mouse, Human
ELISA IP WB
Unconjugated
PDGFRB / PDGFR Beta Antibody IHC-plus™ LS-B5203
Anti-PDGFRB antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5203 concentration 20 ug/ml.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Human
IHC IHC-P
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone APB5) LS-C106587
Staining of NIH-3T3 cells with 0.5 ug Purified Rat IgG2a isotype control (open histogram) or 0.5 ug Purified anti-mouse CD140b (APB5) (colored histogram) followed by Biotin Anti-Rat IgG and Streptavidin-PE. Total viable cells were used for analysis.

Rat Monoclonal [clone APB5] (IgG2a,k) to Mouse PDGFRB / PDGFR Beta
Mouse
Flo IHC IHC-Fr
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone PR7212, CF) LS-C38281

Mouse Monoclonal [clone PR7212] (IgG1) to Human PDGFRB / PDGFR Beta
Human
Flo
CF Conjugated
PDGFRB / PDGFR Beta Antibody (Extracellular Domain, clone PR7212) LS-C11443

Mouse Monoclonal [clone PR7212] (IgG1) to Human PDGFRB / PDGFR Beta
Human, Monkey, Baboon
Flo IHC IHC-Fr IHC-P IP WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (phospho-Tyr751) LS-C178098
IHC of p-PDGFR beta (Y751) pAb in paraffin-embedded human brain tissue.
Western blot of p-PDGFR beta (Y751) pAb in extracts from NIH/3T3 PDGF cells.

Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone 1E8) LS-C338076
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-PDGFRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
IHC of paraffin-embedded Human pancreas tissue using anti-PDGFRB mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Mouse Monoclonal [clone 1E8] (IgG1) to Human PDGFRB / PDGFR Beta
Human
IF IHC IHC-P WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone 18A2, APC) LS-C112600

Mouse Monoclonal [clone 18A2] (IgG1) to Human PDGFRB / PDGFR Beta
Human
Flo
APC Conjugated
PDGFRB / PDGFR Beta Antibody LS-C99116
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PDGFRB antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of PDGFRB Antibody with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Human
IF IHC IHC-P WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (aa991-1040) LS-C117920
IHC of paraffin-embedded human brain tissue, using PDGFR beta (Ab-1021) Antibody. The picture on the right is treated with the synthesized peptide.
Immunofluorescence of COS7 cells, using PDGFR beta (Ab-1021) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (phospho-Tyr751) LS-C117456
IHC of paraffin-embedded human brain, using PDGF Receptor beta (Phospho-Tyr751) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA
Unconjugated
PDGFRB / PDGFR Beta Antibody (phospho-Tyr751) LS-C9622

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
Flo WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (Extracellular Domain, clone 1.A.33) LS-C17316

Mouse Monoclonal [clone 1.A.33] (IgG1) to Human PDGFRB / PDGFR Beta
Human
WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (aa40-72) LS-C99113
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with PDGFRB Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of PDGFRB Antibody with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).

Rabbit Polyclonal to Human PDGFRB / PDGFR Beta
Human
Flo IF IHC IHC-P WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (clone APB5, APC) LS-C107026
Staining of NIH/3T3 cells with 0.25 ug of APC Rat IgG2a isotype control (blue histogram) or 0.25 ug of APC anti-mouse CD140b (PDGFRb) (purple histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone APB5] (IgG2a,k) to Mouse PDGFRB / PDGFR Beta
Mouse
Flo
APC Conjugated
PDGFRB / PDGFR Beta Antibody (clone PR7212, PE) LS-C38280

Mouse Monoclonal [clone PR7212] (IgG1) to Human PDGFRB / PDGFR Beta
Human
Flo
PE Conjugated
PDGFRB / PDGFR Beta Antibody (aa981-1030) LS-C117692
IHC of paraffin-embedded human breast carcinoma tissue, using PDGFRB (Ab-1009) Antibody. The picture on the right is treated with the synthesized peptide.
Immunofluorescence of HeLa cells, using PDGFRB (Ab-1009) Antibody. The picture on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA
Unconjugated
PDGFRB / PDGFR Beta Antibody (phospho-Tyr740) LS-C199421
IHC of paraffin-embedded human colon carcinoma, using PDGFR beta (Phospho-Tyr740) Antibody. The sample on the right was incubated with synthetic peptide.
Western blot of extracts from HepG2 cells treated with EGF 200ng/ml 30', using PDGFR beta (Phospho-Tyr740) Antibody. The lane on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
PDGFRB / PDGFR Beta Antibody LS-C497745

Rabbit Monoclonal to Human PDGFRB / PDGFR Beta
Human
IHC IP WB
Unconjugated
PDGFRB / PDGFR Beta Antibody (Azide-free) LS-C88709

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Human
IHC IHC-P
Unconjugated, Azide-free
PDGFRB / PDGFR Beta Antibody (aa711-760) LS-C117919
Western blot of extracts from Jurkat cells, treated with TNF-a 20 ng/ml 5', using PDGFR beta (Ab-740) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human PDGFRB / PDGFR Beta
Mouse, Rat, Human
Peptide-ELISA WB
Unconjugated
PDGFRB / PDGFR Beta Antibody LS-C163475
PDGFR Antibody western blot of mouse NIH-3T3 cell line lysates (35 ug/lane). The PDGFR antibody detected the PDGFR protein (arrow).

Mouse Monoclonal (IgG1,k) to Mouse PDGFRB / PDGFR Beta
Mouse
WB
Unconjugated

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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