PDGFRA / PDGFR Alpha

platelet-derived growth factor receptor, alpha polypeptide

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

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Products

Proteins (22)

Type

Over-Expression Lysate (2)

Recombinant (20)

Target

PDGFRA / PDGFR Alpha (22)

Application

Bind (1)

ELISA (1)

Func (1)

SDS-PAGE (1)

Publications

No (22)

Tag

6His, C-terminus (2)

DDK (Flag)-His, C-terminus (1)

Fc (1)

Fc, C-terminus (3)

GST (1)

GST, N-terminus (1)

His (3)

His, C-Terminal (1)

His,C-terminus (3)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

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Species

Human (15)

Mouse (4)

Rat (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (3)

HEK 293 Cells (7)

Human Cells (5)

Mammalian Cells (3)

Wheat Germ Extract (2)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (14)

Biologically Active

Biologically active (1)

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His, C-Terminal) (Gln24-Glu524) - LS-G55656

Source:

HEK 293 Cells

Tag:

His, C-Terminal

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57kD

Price:

10 µg/$266; 50 µg/$376; 500 µg/$1,067; 1 mg/$1,369

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Rat PDGFRA / PDGFR Alpha Protein (Recombinant His) (Met1-Glu523) - LS-G98452

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.6 kDa

Price:

100 µg/$843

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His,C-terminus) (Met1-Glu524) - LS-G47910

Source:

HEK 293 Cells

Tag:

His,C-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human PDGFRa consists of 512 amino acids and predicts a molecular mass of 57.7 kDa. By SDS-PAGE under reducing conditions, the apparent molecular mass of rhPDGFRa is approximately 90-100 kDa due to the glycosylation.

Price:

100 µg/$441; 1 mg/$2,003

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His-GST) (Gln551-Leu1089) - LS-G97757

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

89.2 kDa

Price:

50 µg/$707

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His,C-terminus) (Met1-Glu524) - LS-G138083

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57.7 kDa

Price:

100 µg/$721

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Human PDGFRA / PDGFR Alpha Protein (Recombinant Fc, C-terminus) (Met1-Glu524) - LS-G138084

Source:

HEK 293 Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.9 kDa

Price:

100 µg/$721

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PDGFRA / PDGFR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115466

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.67 kDa

Price:

100 µg/$710

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Human PDGFRA / PDGFR Alpha Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142199

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Molecular Weight:

59 kDa

Price:

20 µg/$1,107

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Human PDGFRA / PDGFR Alpha Protein (Recombinant GST) (Full Length) - LS-G29669

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

47.08 kDa

Price:

10 µg/$479; 25 µg/$670

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His-T7) (aa170-387) - LS-G24623

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human PDGFRA / PDGFR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74411

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

122.67 kDa

Price:

20 µg/$215

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Human PDGFRA / PDGFR Alpha Protein (Recombinant GST, N-terminus) (aa105-218) - LS-G59547

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PDGFRA / PDGFR Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64893

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

120.3 kDa

Price:

20 µg/$1,107

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Rat PDGFRA / PDGFR Alpha Protein (Recombinant Fc) (Met1-Glu523) - LS-G98454

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.2 kDa

Price:

100 µg/$843

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His) - LS-G1384

Source:

E. coli

Tag:

His

Price:

10 µg/$361; 50 µg/$739

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Human PDGFRA / PDGFR Alpha Protein (Recombinant His) (aa87-211) - LS-G140970

Source:

E. coli

Sequence Length:

124 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

13.75 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Mouse PDGFRA / PDGFR Alpha Protein (Recombinant Fc, C-terminus) (Leu25-Glu524) - LS-G139270

Source:

Mammalian Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.2 kDa

Price:

10 µg/$281; 50 µg/$389

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Mouse PDGFRA / PDGFR Alpha Protein (Recombinant 6His, C-terminus) (Leu25-Glu524) - LS-G139271

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.9 kDa

Price:

10 µg/$281; 50 µg/$389

Select

Human PDGFRA / PDGFR Alpha Protein (Recombinant His,C-terminus) (Gln24-Glu524) - LS-G139013

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

57 kDa

Price:

10 µg/$266; 50 µg/$371

Select

Mouse PDGFRA / PDGFR Alpha Protein (Recombinant Fc, C-terminus) (Leu25-Glu524) - LS-G40236

Source:

Human Cells

Tag:

Fc, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

83.2kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

Select

Mouse PDGFRA / PDGFR Alpha Protein (Recombinant 6His, C-terminus) (Leu25-Glu524) - LS-G40251

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.9kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

Select

Human PDGFRA / PDGFR Alpha Protein (Recombinant) (Met1-Glu524) - LS-G97758

Source:

Human Cells

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

56.8 kDa

Price:

100 µg/$721

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