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Unfortunately, the antibody (ID:155976) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



PDGFRA / PDGFR Alpha

platelet-derived growth factor receptor, alpha polypeptide

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Family/Subfamily: Protein Kinase , PDGF Receptor
Synonyms: PDGFRA, CD140A, CD140a antigen, PDGFalphaR, PDGFR2, PDGFRalpha, AlphaPDGFR, RHEPDGFRA, PDGF receptor alpha, PDGFR-2, PDGFRA/BCR fusion, APDGFR, Pdgf alpha-receptor, PDGF-R-alpha, PDGFR-alpha
Target Sequences: NM_006206 NP_006197.1 P16234

Publications (2)

1
Imatinib mesylate plus hydroxyurea chemotherapy for cerebellar meningioma in a Belgian Malinois dog. Jung HW, Lee HC, Kim JH, Jang HM, Moon JH, Sur JH, Ha J, Jung DI. The Journal of veterinary medical science. 2014 76:1545-8. (IHC; Canine) [PubMed:25131949] [PMC:PMC4272992] Related Antibodies: LS-B6056.
2
A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor alpha gene as a quantitative trait locus for eye size in white Europeans. Guggenheim JA, McMahon G, Kemp JP, Akhtar S, St Pourcain B, Northstone K, Ring SM, Evans DM, Smith GD, Timpson NJ, Williams C. Molecular vision. 2013 19:243-53. [Full Text Article] [PubMed:23401653] [PMC:PMC3566893] Related Antibodies: LS-B6056.

Filtered By: None
Target
pdgfra-pdgfr-alpha (193)
Reactivity
Human (172)
Mouse (83)
Rat (41)
Bat (1)
Bovine (3)
Chicken (2)
Dog (3)
Hamster (1)
Horse (2)
Monkey (2)
Pig (3)
Rabbit (1)
Sheep (1)
Xenopus (1)
Application
IHC (99)
IHC-Fr (1)
IHC-P (22)
WB (142)
Flo (26)
DB (7)
ELISA (89)
ICC (12)
IF (18)
IP (9)
Peptide-ELISA (7)
Host
rabbit (143)
mouse (39)
rat (11)
Isotype
IgG (107)
IgG1 (19)
IgG1,k (1)
IgG2a (3)
IgG2a,k (11)
IgG2b (2)
Clonality
monoclonal mc (51)
polyclonal pc (142)
Clone
16A1 (5)
1A10A8 (1)
1A11 (1)
1H10 (1)
2B12 (1)
2D2-1A11 (1)
2E9 (1)
35248 (57/20) (1)
3F4 (1)
4E7 (1)
4G5 (1)
5B11G5 (1)
6E2 (1)
8E12F2 (1)
APA5 (4)
Format
AP Conjugated (12)
APC (3)
APC Conjugated (18)
Azide-free (7)
Biotin Conjugated (19)
CF Conjugated (1)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (19)
HRP Conjugated (16)
PE Conjugated (18)
Unconjugated (84)
Epitope
aa170-387 (10)
pTyr762 (9)
Tyr720 (8)
Tyr754 (8)
Tyr762 (8)
Tyr768 (8)
aa1048-1077 (8)
aa678-706 (8)
C-Terminus (5)
aa789-1089 (5)
pTyr754 (4)
pTyr849 (4)
aa32-324 (3)
aa1035-1053 (2)
pTyr742 (2)
Extracellular Domain (1)
Ile843 (1)
Ser1057 (1)
aa1010-1090 (1)
aa1031-1080 (1)
aa1063-1077 (1)
aa351-400 (1)
aa690-770 (1)
aa700-780 (1)
aa721-770 (1)
aa731-780 (1)
aa790-870 (1)
aa816-865 (1)
aa960-1040 (1)
aa968-1002 (1)
pTyr1018 (1)
Publications
No (192)
Yes (1)
Showing 1-25 out of 193 results
Anti-PDGFRA / PDGFR Alpha Antibody (aa1035-1053) IHC-plus™ LS-B6056
Anti-PDGFRA antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6056 dilution 1:100.

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Xenopus, Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC IHC-P IP WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (C-Terminus) IHC-plus™ LS-B2172
Anti-PDGFRA antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2172 concentration 5 ug/ml.

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Mouse, Rat, Human
IHC IHC-P
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (aa1063-1077) IHC-plus™ LS-B857
Anti-PDGFRA antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B857 concentration 5 ug/ml.
Anti-PDGFRA antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B857 concentration 5 ug/ml.

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Human
ELISA IHC IHC-P
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone APA5) LS-C106627
Staining of NIH/3T3 cells with 0.5 ug of Purified Rat IgG2a isotype control (open histogram) or 0.5 ug of Purified anti-mouse CD140a (APA5) (colored histogram) followed by Biotin Anti-Rat IgG and SAv-PE. Total viable cells were used for analysis.

Rat Monoclonal [clone APA5] (IgG2a,k) to Mouse PDGFRA / PDGFR Alpha
Mouse
Flo IHC IHC-Fr WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Extracellular Domain, clone 35248 (57/20)) LS-C11204

Mouse Monoclonal [clone 35248 (57/20)] (IgG1) to Human PDGFRA / PDGFR Alpha
Human
ELISA IHC IHC-P WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone APA5, PE) LS-C106101
Staining of NIH/3T3 cells with 0.5 ug of PE Rat IgG2a isotype control (open histogram) or 0.5 ug of PE anti-mouse CD140a (APA5) (colored histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone APA5] (IgG2a,k) to Mouse PDGFRA / PDGFR Alpha
Mouse
Flo
PE Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (phospho-Tyr754) LS-C38277

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Mouse, Human
WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody IHC-plus™ LS-B4840
Anti-PDGFRA antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4840 concentration 10 ug/ml.
Anti-PDGFRA antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4840 concentration 10 ug/ml.

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Human
IHC IHC-P WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (C-Terminus) LS-C74981

Rabbit Monoclonal (IgG) to Human PDGFRA / PDGFR Alpha
Mouse, Human
Flo IF IHC IHC-P IP WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone APA5, Biotin) LS-C106208
Surface staining of NIH/3T3 cells with 0.5 ug Biotin anti-mouse CD140a (APA5) followed by SA-PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone APA5] (IgG2a,k) to Mouse PDGFRA / PDGFR Alpha
Mouse
Flo
Biotin Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone 16A1, APC) LS-C112597

Mouse Monoclonal [clone 16A1] (IgG1) to Human PDGFRA / PDGFR Alpha
Human
Flo
APC Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (aa700-780) LS-C385416
Western blot of PDGFR-alpha antibody

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (aa32-324, clone 2E9) IHC-plus™ LS-B14322
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

Mouse Monoclonal [clone 2E9] (IgG2a) to Human PDGFRA / PDGFR Alpha
Human
IHC IHC-P WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody IHC-plus™ LS-B8655
Anti-PDGFRA / PDGFR Alpha antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8655 dilution 5 ug/ml.

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Mouse, Human
IHC IHC-P
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone 16A1) LS-C112438

Mouse Monoclonal [clone 16A1] (IgG1) to Human PDGFRA / PDGFR Alpha
Human
Flo ICC
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (C-Terminus) IHC-plus™ LS-B2683
Anti-PDGFRA antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2683 concentration 5 ug/ml.

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Mouse, Human
ELISA IHC IHC-P
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (clone APA5, APC) LS-C107240
Staining of NIH-3T3 cells with 0.5 ug of APC Rat IgG2a isotype control (open histogram) or 0.5 ug of APC anti-mouse CD140a (APA5) (colored histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rat Monoclonal [clone APA5] (IgG2a,k) to Mouse PDGFRA / PDGFR Alpha
Mouse
Flo
APC Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody LS-C14255

Rat Monoclonal (IgG2a,k) to Mouse PDGFRA / PDGFR Alpha
Mouse
ELISA Flo IHC WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody LS-C415937
Western blot of 293 cell lysate using PDGFRalpha Antibody

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (aa1048-1077) LS-C99100
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of PDGFRA Antibody (C-term E1063) in K562 cell line lysates (35 ug/lane). PDGFRA (arrow) was detected using the purified antibody.

Rabbit Polyclonal to Human PDGFRA / PDGFR Alpha
Mouse, Human
Flo IHC IHC-P WB
Unconjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Tyr754, Biotin) LS-C281066

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human
ELISA ICC IF IHC WB
Biotin Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Tyr754, FITC) LS-C281065

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human
ELISA ICC IF IHC WB
FITC Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Tyr754, APC) LS-C281064

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human
ELISA ICC IF IHC WB
APC Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Tyr754, PE) LS-C281069

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human
ELISA ICC IF IHC WB
PE Conjugated
Anti-PDGFRA / PDGFR Alpha Antibody (Tyr754, Azide-free, HRP) LS-C281067

Rabbit Polyclonal (IgG) to Human PDGFRA / PDGFR Alpha
Human
ELISA ICC IF IHC WB
HRP Conjugated, Azide-free

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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