PDF / PLAB

Peptide Deformylase (mitochondrial)

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.

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Antibodies (19)

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Primary (19)

Target

PDF / PLAB (19)

Reactivity

Human (19)

Mouse (1)

Rat (1)

Application

IHC (2)

IHC-P (2)

WB (15)

Flo (4)

ELISA (7)

IF (4)

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rabbit (15)

mouse (4)

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IgG (12)

IgG1 (2)

IgG2b (2)

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monoclonal mc (4)

polyclonal pc (15)

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OTI3C12 (2)

OTI3F3 (2)

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Azide-free (1)

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HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (11)

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aa125-151 (7)

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No (19)

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PDF / PLAB Antibody (clone OTI3F3) LS-C173000

Antibody:

PDF / PLAB Mouse anti-Human Monoclonal (OTI3F3) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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PDF / PLAB Antibody (clone OTI3F3, Carrier-free) LS-C786076

Antibody:

PDF / PLAB Mouse anti-Human Monoclonal (Carrier-free) (OTI3F3) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PDF / PLAB Antibody LS-C816937

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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PDF / PLAB Antibody (clone OTI3C12) LS-C173001

Antibody:

PDF / PLAB Mouse anti-Human Monoclonal (OTI3C12) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

100 µl/$434

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PDF / PLAB Antibody (clone OTI3C12, Carrier-free) LS-C786078

Antibody:

PDF / PLAB Mouse anti-Human Monoclonal (Carrier-free) (OTI3C12) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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PDF / PLAB Antibody LS-C674091

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PDF / PLAB Antibody (HRP) LS-C674090

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PDF / PLAB Antibody (Biotin) LS-C674093

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PDF / PLAB Antibody (FITC) LS-C674092

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PDF / PLAB Antibody (C-Terminus) LS-C144922

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

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PDF / PLAB Antibody (aa125-151) LS-C323896

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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PDF / PLAB Antibody (aa125-151, Biotin) LS-C238889

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PDF / PLAB Antibody (aa125-151, FITC) LS-C238890

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PDF / PLAB Antibody (aa125-151, APC) LS-C238887

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PDF / PLAB Antibody (aa125-151, PE) LS-C238895

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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PDF / PLAB Antibody (aa125-151, Azide-free, HRP) LS-C248442

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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PDF / PLAB Antibody (aa125-151) LS-C158562

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal (aa125-151) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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PDF / PLAB Antibody LS-C668872

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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PDF / PLAB Antibody LS-C497168

Antibody:

PDF / PLAB Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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