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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
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Additional Contact Details
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PDE8B
phosphodiesterase 8B
PDE8B is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | phosphodiesterase 8B |
| Family/Subfamily: | Phosphodiesterase , PDE - cAMP-specific, high affinity |
| Synonyms: | PDE8B, ADSD, HsPDE8B, PPNAD3, Phosphodiesterase 8B |
| Target Sequences: | AF079529 AAC69564.2 O95263 |
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