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PDE6A / PDE6 Alpha

phosphodiesterase 6A, cGMP-specific, rod, alpha

PDE6A is the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Gene Name: phosphodiesterase 6A, cGMP-specific, rod, alpha
Family/Subfamily: Phosphodiesterase , PDE - photoreceptor
Synonyms: PDE6A, Alpha-PDE, CGMP phosphodiesterase alpha, CGPR-A, PDE6alpha, PDE V-B1, PDEA, Phosphodiesterase 6a, RP43, GMP-PDE alpha
Target Sequences: NM_000440 NP_000431.2 P16499

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Proteins (3)
Over-Expression Lysate (2)
Recombinant (1)
PDE6A / PDE6 Alpha (3)
No (3)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
PDE6A / PDE6 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
99.4 kDa
100 µg/$494
PDE6A / PDE6 Alpha Protein
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E. coli
His, N-Terminal
99.4 kDa
50 µg/$419
PDE6A / PDE6 Alpha Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
99.4 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).