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PDE3A

phosphodiesterase 3A, cGMP-inhibited

PDE3A is a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name: phosphodiesterase 3A, cGMP-inhibited
Family/Subfamily: Phosphodiesterase , PDE - cAMP/cGMP dual-specific, cGMP-inhibited
Synonyms: PDE3A, CGI-PDE-A, HcGIP2, Phosphodiesterase 3a, Phosphodiesterase isoform 3a, CGI-PDE, CGI-PDE A, CGIP2, HPDE-3A, Phosphodiesterase type 3A
Target Sequences: NM_000921 NP_000912.3 Q14432

Publications (1)

1
Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. Mahmood B, Damm MM, Jensen TS, Backe MB, Dahllöf MS, Poulsen SS, Bindslev N, Hansen MB. BMC cancer. 2016 16:938. (IHC; Human) [Full Text Article] [PubMed:27927168] [PMC:PMC5141637] Related Antibodies: LS-A732.

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Antibodies (15)
Proteins (5)
ELISA Kits (1)
Over-Expression Lysate (2)
Primary (15)
Recombinant (3)
Sandwich (1)
PDE3A (21)
Human (15)
Mouse (4)
Rat (5)
Bovine (3)
Chimpanzee (3)
Horse (4)
Monkey (5)
Pig (3)
IHC (5)
IHC-P (4)
WB (10)
ELISA (3)
IF (1)
IP (3)
Peptide-ELISA (1)
rabbit (14)
mouse (1)
Product Group
IHCPlus (3)
IgG (4)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (14)
5C12 (1)
96-Well Strip Plate (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (12)
aa360-409 (4)
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C-Terminus (1)
Internal (1)
aa450-500 (1)
aa575-625 (1)
aa609-901 (1)
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GST, N-terminus (1)
His-GST (1)
His-GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
Rat (1)
293T Cells (1)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
PDE3A Antibody - Anti-PDE3A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PDE3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
PDE3A Antibody - Anti-PDE3A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PDE3A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
PDE3A Antibody - Anti-PDE3A antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PDE3A Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
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PDE3A Rabbit anti-Human Polyclonal (aa450-500) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PDE3A Antibody - Detection limit for recombinant GST tagged PDE3A is approximately 0.1 ng/ml as a capture antibody.
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PDE3A Mouse anti-Human Monoclonal (5C12) Antibody
Human
ELISA
Unconjugated
100 µg/$423
PDE3A Antibody
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PDE3A Rabbit anti-Human Polyclonal (aa609-901) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$332
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PDE3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
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PDE3A Rabbit anti-Human Polyclonal (aa575-625) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
PDE3A Antibody - Immunohistochemistry of paraffin-embedded Rat kidney using PDE3A Polyclonal Antibody at dilution of 1:100 (40x lens).
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PDE3A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PDE3A Antibody - Western blot of PDE3A antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.
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PDE3A Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$469
PDE3A Antibody - Western blot analysis of PDE3A using COS7 whole cells lysates
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PDE3A Rabbit anti-Human Polyclonal Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PDE3A Antibody - PDE3A antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDE3A Rabbit anti-Human Polyclonal (aa360-409) Antibody
Human
WB
Unconjugated
100 µl/$424
PDE3A Antibody - PDE3A antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDE3A Rabbit anti-Human Polyclonal (aa360-409) (HRP) Antibody
Bovine, Pig, Horse, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$469
PDE3A Antibody - PDE3A antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDE3A Rabbit anti-Human Polyclonal (aa360-409) (Biotin) Antibody
Bovine, Pig, Horse, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
PDE3A Antibody - PDE3A antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDE3A Rabbit anti-Human Polyclonal (aa360-409) (FITC) Antibody
Bovine, Pig, Horse, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
PDE3A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PDE3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
124.8 kDa
20 µg/$215
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
81.7 kDa
100 µg/$843
PDE3A Protein - Recombinant Phosphodiesterase 3A, cGMP Inhibited (PDE3A) by SDS-PAGE
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E. coli
His-GST, N-terminus
51.9kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
PDE3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
124.8 kDa
100 µg/$710
PDE3A ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$893
Viewing 1-21 of 21 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).