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PDE2A

phosphodiesterase 2A, cGMP-stimulated

Phosphodiesterase 2A is a cGMP stimulated, cAMP/cGMP dual-specific phosphodiesterase whose hydrolytic activity is stimulated by the presence of cGMP binding to the GAF domain. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transit across the endothelial cell barrier (i. e., venous and capillary). PDE2A activity is inhibited by erythro-9-(2-hydroxyl-3-nonyl)adenine (EHNA). At least three isoforms have been reported (PDE2A1, PDE2A2, and PDE2A3).

Gene Name: phosphodiesterase 2A, cGMP-stimulated
Family/Subfamily: Phosphodiesterase , PDE - cAMP/cGMP dual-specific, cGMP-stimulated
Synonyms: PDE2A, CGMP-stimulated PDE, Cyclic GMP-stimulated PDE, PDE2, Pde2a2, PED2A4, Phosphodiesterase 2A, CGS-PDE, CGSPDE, PDE2A1, Pde2a3
Target Sequences: NM_002599 NP_002590.1 O00408

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
PDE2A (4)
No (4)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
PDE2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
105.5 kDa
100 µg/$494
PDE2A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
PDE2A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
105.5 kDa
20 µg/$150
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Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
80.0 kDa
50 µg/$721
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).