PDCD6IP / ALIX

programmed cell death 6 interacting protein

Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PDCD6IP / ALIX (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST-S (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PDCD6IP / ALIX Protein (Recombinant GST) (Full Length) - LS-G31900

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

121.11 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse PDCD6IP / ALIX Protein (Recombinant His-T7) (aa1-239) - LS-G13544

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.3 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human PDCD6IP / ALIX Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G61325

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PDCD6IP / ALIX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89834

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.8 kDa

Price:

20 µg/$150

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PDCD6IP / ALIX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114299

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.8 kDa

Price:

100 µg/$494

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Human PDCD6IP / ALIX Protein (Recombinant His-GST-S) (aa174-383) - LS-G24254

Source:

E. coli

Tag:

His-GST-S

Molecular Weight:

53.8 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human PDCD6IP / ALIX Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71463

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.8 kDa

Price:

20 µg/$1,107

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Human PDCD6IP / ALIX Protein (Recombinant His) - LS-G703

Source:

E. coli

Tag:

His

Price:

100 µg/$342; 500 µg/$641; 20 µg/$254

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