PDCD6IP / ALIX

programmed cell death 6 interacting protein

Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.

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Products

ELISA Kits (2)

Type

Sandwich (2)

Target

PDCD6IP / ALIX (2)

Reactivity

Human (2)

Format

96-Well Strip Plate (2)

Publications

No (2)

Sample Type

Cell Lysates (2)

Plasma (1)

Serum (1)

Tissue Homogenates (2)

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Human PDCD6IP / ALIX (Sandwich ELISA) ELISA Kit - LS-F52391

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

47 - 3000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

Select

Human PDCD6IP / ALIX (Sandwich ELISA) ELISA Kit - LS-F7886

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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