PCSK9

proprotein convertase subtilisin/kexin type 9

Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.

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Products

Proteins (22)

Type

Over-Expression Lysate (2)

Recombinant (20)

Target

PCSK9 (22)

Publications

No (22)

Tag

6His, C-terminus (7)

6His-HA-AVI, C-terminus (1)

AVI, C-terminus (1)

DDK (Flag)-His, C-terminus (1)

GST (1)

His (3)

His,C-terminus (2)

His-GST (1)

His-GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (13)

Mouse (4)

Rat (2)

Southern pig-tailed macaque (2)

Source

293T Cells (1)

CHO Cells (1)

E. coli (4)

HEK 293 Cells (4)

Human Cells (5)

Mammalian Cells (6)

Wheat Germ Extract (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (13)

Biologically Active

Biologically active (1)

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Rat PCSK9 Protein (Recombinant His-GST, N-terminus) (Trp164-Phe428) - LS-G25431

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

58.1 kDa

Price:

10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329

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Southern pig-tailed macaque PCSK9 Protein (Recombinant 6His, C-terminus) (Gln31-Gln152) - LS-G51836

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

14&59kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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Mouse PCSK9 Protein (Recombinant 6His, C-terminus) (Gln35-Gln692) - LS-G39342

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

74.8kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157

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Human PCSK9 Protein (Recombinant 6His, C-terminus) (Gln31-Gln692) - LS-G39343

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.1kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human PCSK9 Protein (Recombinant 6His, C-terminus) (Gln31-Gln692) - LS-G39338

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.05kD

Price:

10 µg/$288; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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Human PCSK9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82752

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71 kDa

Price:

20 µg/$215

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Human PCSK9 Protein (Recombinant His) (aa454-679) - LS-G15436

Source:

E. coli

Tag:

His

Molecular Weight:

25.4 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Human PCSK9 Protein (Recombinant His) (aa156-461) - LS-G15437

Source:

E. coli

Tag:

His

Molecular Weight:

34.2 kDa

Price:

10 µg/$288; 50 µg/$487; 100 µg/$780; 200 µg/$972; 1 mg/$2,109; 500 µg/$1,636; 5 mg/$3,403; 2 mg/$2,298

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Mouse PCSK9 Protein (Recombinant His-GST) (aa156-694) - LS-G25430

Source:

E. coli

Tag:

His-GST

Molecular Weight:

87.3 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Human PCSK9 Protein (Recombinant GST) (Full Length) - LS-G37130

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

99.2 kDa

Price:

10 µg/$479; 25 µg/$670

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PCSK9 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102449

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71 kDa

Price:

100 µg/$710

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Human PCSK9 Protein (Recombinant) - LS-G137635

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1 EU/µg (determined by LAL method).

Molecular Weight:

Predicted molecular mass of approximately 73 kD. It migrates as 70 and 17 kD for mature and prodomain, respectively, in DTT-reducing conditions and 63 and 17 kD in non-reducing conditions by SDS-PAGE.

Price:

10 µg/$355; 25 µg/$497; 100 µg/$1,186; 500 µg/$3,043

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Mouse PCSK9 Protein (Recombinant His,C-terminus) (Met1-Gln694) - LS-G138397

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.6 kDa

Price:

20 µg/$382; 100 µg/$1,007

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Human PCSK9 Protein (Recombinant 6His-HA-AVI, C-terminus) (Gln31-Gln152) - LS-G140351

Source:

Mammalian Cells

Tag:

6His-HA-AVI, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

20 µg/$466; 100 µg/$1,103

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Human PCSK9 Protein (Recombinant AVI, C-terminus) (Gln31-Gln152) - LS-G140352

Source:

Mammalian Cells

Tag:

AVI, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

20 µg/$466; 100 µg/$1,103

Select

Mouse PCSK9 Protein (Recombinant 6His, C-terminus) (Gln35-Gln155) - LS-G140649

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.4 kDa

Price:

10 µg/$344; 50 µg/$584

Select

Southern pig-tailed macaque PCSK9 Protein (Recombinant His,C-terminus) (Gln31-Gln152) - LS-G140702

Source:

Mammalian Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

10 µg/$344; 50 µg/$584

Select

Human PCSK9 Protein (Recombinant 6His, C-terminus) (Gln31-Gln152) - LS-G139144

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

73 kDa

Price:

10 µg/$376; 50 µg/$479

Select

Human PCSK9 Protein (Recombinant 6His, C-terminus) (Gln31-Gln692) - LS-G139676

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

71.1 kDa

Price:

10 µg/$376; 50 µg/$526

Select

Human PCSK9 Protein (Recombinant DDK (Flag)-His, C-terminus) - LS-G142183

Source:

HEK 293 Cells

Tag:

DDK (Flag)-His, C-terminus

Price:

20 µg/$1,107

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Rat PCSK9 Protein (Recombinant His) (Met1-Gln691) - LS-G98870

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72.8 kDa

Price:

20 µg/$483

Select

Human PCSK9 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68674

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

71 kDa

Price:

20 µg/$1,107

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