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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PCSK4

proprotein convertase subtilisin/kexin type 4

PCSK4 / PC4 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II.

Gene Name: proprotein convertase subtilisin/kexin type 4
Family/Subfamily: Protease , Serine S8
Synonyms: PCSK4, PC4, Proprotein convertase 4, SPC5
Target Sequences: BC036354 AAH36354.1 Q6UW60

Filtered by: None
Target
PCSK4 (14)
Reactivity
Human (13)
Mouse (5)
Rat (4)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Monkey (4)
Application
WB (14)
ELISA (8)
Host
rabbit (14)
Isotype
IgG (8)
Clonality
polyclonal pc (14)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (5)
Epitope
aa168-196 (8)
aa35-84 (4)
aa117-133 (1)
Publications
No (14)
Showing 1-14 of 14 results

PCSK4 Antibody (aa168-196) LS-C323864
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
Unconjugated
200µl  $590.00

PCSK4 Antibody (aa168-196, Biotin) LS-C238864
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

PCSK4 Antibody (aa168-196, FITC) LS-C238865
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

PCSK4 Antibody (aa168-196, AP) LS-C238862
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
AP Conjugated
200µl  $740.00

PCSK4 Antibody (aa168-196, PE) LS-C238866
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
PE Conjugated
200µl  $740.00

PCSK4 Antibody (aa168-196, APC) LS-C238863
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
APC Conjugated
200µl  $740.00

PCSK4 Antibody (aa168-196, Azide-free, HRP) LS-C248438
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

PCSK4 Antibody LS-C754345
Rabbit Polyclonal (IgG) to Human PCSK4
Human
ELISA, WB
Unconjugated
100µg  $355.00

PCSK4 Antibody (aa117-133) LS-C313227
Rabbit Polyclonal to Mouse PCSK4
Mouse
WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
WB of PCSK4 / PC4 antibody. WB: Rat Brain Tissue.
Western blot analysis of PCSK4 using anti-PCSK4 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: rat brain lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-PCSK4 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for PCSK4 at approximately 83KD. The expected band size for PCSK4 is at 83KD.

PCSK4 Antibody (aa168-196) LS-C163449
Rabbit Polyclonal to Human PCSK4
Human
WB
Unconjugated
400µl  $325.00
PCSK4 Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The PCSK4 antibody detected the PCSK4 protein (arrow).

PCSK4 Antibody (aa35-84) LS-C112229
Rabbit Polyclonal to Human PCSK4
Mouse, Dog, Bovine, Rat, Bat, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
PCSK4 / PC4 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PCSK4 Antibody (aa35-84, HRP) LS-C465316
Rabbit Polyclonal to Human PCSK4
Mouse, Dog, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
PCSK4 / PC4 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PCSK4 Antibody (aa35-84, Biotin) LS-C465314
Rabbit Polyclonal to Human PCSK4
Mouse, Dog, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
PCSK4 / PC4 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

PCSK4 Antibody (aa35-84, FITC) LS-C465315
Rabbit Polyclonal to Human PCSK4
Mouse, Dog, Bovine, Rat, Bat, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
PCSK4 / PC4 antibody Western blot of OVCAR-3 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Showing 1-14 of 14 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).