PCSK2

proprotein convertase subtilisin/kexin type 2

PCSK2 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Products

Antibodies (16)

Type

Primary (16)

Target

PCSK2 (16)

Reactivity

Human (16)

Mouse (6)

Rat (5)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (3)

IHC-P (3)

WB (13)

Flo (2)

ELISA (3)

IF (1)

IP (1)

Peptide-ELISA (1)

Host

rabbit (14)

mouse (2)

Isotype

IgG (8)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (2)

polyclonal pc (14)

Clone

11n157 (1)

3H4 (1)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Serum (1)

Unconjugated (10)

Epitope

aa351-400 (4)

aa110-638 (1)

aa318-346 (1)

aa87-116 (1)

Publications

No (16)

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PCSK2 Antibody (aa87-116) LS-C100271

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa87-116) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PCSK2 Antibody LS-C674195

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (HRP) LS-C674196

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (Biotin) LS-C674200

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (FITC) LS-C674198

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PCSK2 Antibody (aa318-346) LS-C100272

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa318-346) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PCSK2 Antibody (clone 3H4) LS-C197856

Antibody:

PCSK2 Mouse anti-Human Monoclonal (3H4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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PCSK2 Antibody LS-C754306

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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PCSK2 Antibody (aa110-638, clone 11n157) LS-C184874

Antibody:

PCSK2 Mouse anti-Human Monoclonal (aa110-638) (11n157) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µg/$884

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PCSK2 Antibody LS-C809108

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PCSK2 Antibody (Serum) LS-C42693

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (Serum) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Serum

Price:

0.1 ml/$535

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PCSK2 Antibody (aa351-400) LS-C135548

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PCSK2 Antibody (aa351-400, HRP) LS-C466431

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PCSK2 Antibody (aa351-400, Biotin) LS-C466429

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PCSK2 Antibody (aa351-400, FITC) LS-C466430

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PCSK2 Antibody LS-C410178

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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