PCSK2

proprotein convertase subtilisin/kexin type 2

PCSK2 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Products

Antibodies (16)

Proteins (6)

ELISA Kits (2)

Type

Over-Expression Lysate (2)

Primary (16)

Recombinant (4)

Sandwich (2)

Target

PCSK2 (24)

Reactivity

Human (18)

Mouse (6)

Rat (5)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (3)

IHC-P (3)

WB (13)

Flo (2)

ELISA (3)

IF (1)

IP (1)

Peptide-ELISA (1)

Host

rabbit (14)

mouse (2)

Isotype

IgG (8)

IgG2a,k (1)

IgG2b (1)

Clonality

monoclonal mc (2)

polyclonal pc (14)

Clone

11n157 (1)

3H4 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Serum (1)

Unconjugated (10)

Epitope

aa351-400 (4)

aa110-638 (1)

aa318-346 (1)

aa87-116 (1)

Publications

No (24)

Sample Type

Cell Culture Supernatants (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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PCSK2 Antibody (aa87-116) LS-C100271

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa87-116) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human PCSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G92321

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.57 kDa

Price:

20 µg/$215

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Human PCSK2 (Sandwich ELISA) ELISA Kit - LS-F9472

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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PCSK2 Antibody LS-C674195

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (HRP) LS-C674196

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (Biotin) LS-C674200

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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PCSK2 Antibody (FITC) LS-C674198

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PCSK2 Antibody (aa318-346) LS-C100272

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa318-346) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PCSK2 Antibody (clone 3H4) LS-C197856

Antibody:

PCSK2 Mouse anti-Human Monoclonal (3H4) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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PCSK2 Antibody LS-C754306

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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PCSK2 Antibody (aa110-638, clone 11n157) LS-C184874

Antibody:

PCSK2 Mouse anti-Human Monoclonal (aa110-638) (11n157) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µg/$884

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PCSK2 Antibody LS-C809108

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PCSK2 Antibody (Serum) LS-C42693

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (Serum) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Serum

Price:

0.1 ml/$535

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PCSK2 Antibody (aa351-400) LS-C135548

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PCSK2 Antibody (aa351-400, HRP) LS-C466431

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PCSK2 Antibody (aa351-400, Biotin) LS-C466429

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PCSK2 Antibody (aa351-400, FITC) LS-C466430

Antibody:

PCSK2 Rabbit anti-Human Polyclonal (aa351-400) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Pig, Horse, Bat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey, Gibbon, Orangutan, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PCSK2 Antibody LS-C410178

Antibody:

PCSK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human PCSK2 (Sandwich ELISA) ELISA Kit - LS-F50010

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.458 - 600 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$672

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Rat PCSK2 Protein (Recombinant 6His, N-terminus) (aa109-637) - LS-G64388

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Human PCSK2 Protein (Recombinant GST, N-terminus) (aa501-609) - LS-G59530

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PCSK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72422

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67.9 kDa

Price:

20 µg/$1,107

Select

Human PCSK2 Protein (Recombinant GST) (Full Length) - LS-G29652

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

93.83 kDa

Price:

10 µg/$479; 25 µg/$670

Select

PCSK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117865

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.57 kDa

Price:

100 µg/$710

Viewing 1-24 of 24 product results

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