PCSK1N / PROSAAS

proprotein convertase subtilisin/kexin type 1 inhibitor

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known.

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Products

Antibodies (7)

Type

Primary (7)

Target

PCSK1N / PROSAAS (7)

Reactivity

Human (6)

Mouse (3)

Rat (4)

Monkey (1)

Application

IHC (2)

IHC-P (2)

WB (5)

ELISA (2)

Peptide-ELISA (1)

Host

rabbit (5)

mouse (1)

goat (1)

Product Group

IHCPlus (1)

Isotype

IgG (1)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (6)

Clone

1E9 (1)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (4)

Epitope

aa54-103 (4)

aa182-193 (1)

aa221-242 (1)

Publications

No (7)

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IHC-plus™ PCSK1N / PROSAAS Antibody (aa182-193) LS-B10595

(4.0) Rating

Antibody:

PCSK1N / PROSAAS Goat anti-Human Polyclonal (aa182-193) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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PCSK1N / PROSAAS Antibody (aa54-103) LS-C170303

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PCSK1N / PROSAAS Antibody (aa54-103, HRP) LS-C465969

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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PCSK1N / PROSAAS Antibody (aa54-103, Biotin) LS-C465967

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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PCSK1N / PROSAAS Antibody (aa54-103, FITC) LS-C465968

Antibody:

PCSK1N / PROSAAS Rabbit anti-Rat Polyclonal (aa54-103) (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PCSK1N / PROSAAS Antibody (clone 1E9) LS-C134062

Antibody:

PCSK1N / PROSAAS Mouse anti-Human Monoclonal (1E9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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PCSK1N / PROSAAS Antibody (aa221-242) LS-C144116

Antibody:

PCSK1N / PROSAAS Rabbit anti-Human Polyclonal (aa221-242) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Unconjugated

Price:

200 µg/$1,027

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