PCSK1

proprotein convertase subtilisin/kexin type 1

PCSK1 is a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene

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ELISA Kits (2)

Type

Sandwich (2)

Target

PCSK1 (2)

Reactivity

Human (1)

Rat (1)

Format

96-Well Strip Plate (2)

Publications

No (2)

Sample Type

Plasma (2)

Serum (2)

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Human PCSK1 (Sandwich ELISA) ELISA Kit - LS-F6711

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$834

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Rat PCSK1 (Sandwich ELISA) ELISA Kit - LS-F8656

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

3.13 - 200 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$893

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