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Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity.
Gene Name: | procollagen C-endopeptidase enhancer |
Synonyms: | PCOLCE, PCPE, PCPE-1, PCPE1 |
Target Sequences: | NM_002593 NP_002584.2 Q15113 |
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